5VWW

Bak core latch dimer in complex with Bim-RT - Tetragonal

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	Bcl-2 homologous antagonist/killer	polymer	170	19037.3	2	UniProt (Q16611) Pfam (PF00452)	Homo sapiens (Human)	Apoptosis regulator BAK,Bcl-2-like protein 7,Bcl2-L-7
2	C, D (C, D)	Bcl-2-like protein 11	polymer	26	3183.6	2	UniProt (O43521) Pfam (PF08945)	Homo sapiens	Bcl2-L-11,Bcl2-interacting mediator of cell death
3	E (A)	(4S)-2-METHYL-2,4-PENTANEDIOL	non-polymer		118.2	1	Chemie (MPD)
4	F, H (A, C)	BROMIDE ION	non-polymer		79.9	2	Chemie (BR)
5	G (A)	IMIDAZOLE	non-polymer		69.1	1	Chemie (IMD)
6	I, J, K (A, B, C)	water	water		18.0	19	Chemie (HOH)

Sequence modifications

A, B: 23 - 186 (UniProt: Q16611)

PDB	External Database	Details
Gly 17	-	expression tag
Pro 18	-	expression tag
Leu 19	-	expression tag
Gly 20	-	expression tag
Ser 21	-	expression tag
Met 22	-	expression tag
Ser 166	Cys 166	engineered mutation

C, D: 141 - 166 (UniProt: O43521)

PDB	External Database	Details
Arg 147	Trp 147	engineered mutation
Thr 162	Tyr 162	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	44441.8
Non-Polymers*	Number of molecules	4
	Total formula weight	347.1
All*	Total formula weight	44788.9

*Water molecules are not included.