5VVB

Structure of human endothelial nitric oxide synthase heme domain in complex with 4-(2-(((2-Aminoquinolin-7-yl)methyl)amino)ethyl)-2-methylbenzonitrile

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C, D	Nitric oxide synthase, endothelial	polymer	440	49345.8	4	UniProt (P29474) Pfam (PF02898) In PDB	Homo sapiens (Human)	Constitutive NOS,cNOS,EC-NOS,Endothelial NOS,eNOS,NOS type III,NOSIII
2	A, D, B, C	PROTOPORPHYRIN IX CONTAINING FE	non-polymer		616.5	4	Chemie (HEM)
3	A, D, B, C	5,6,7,8-TETRAHYDROBIOPTERIN	non-polymer		241.2	4	Chemie (H4B)
4	A, D, B, C	4-(2-{[(2-aminoquinolin-7-yl)methyl]amino}ethyl)-2-methylbenzonitrile	non-polymer		316.4	4	Chemie (9P7)
5	A, D, B, C	2-[BIS-(2-HYDROXY-ETHYL)-AMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL	non-polymer		209.2	9	Chemie (BTB)
6	C, A	ZINC ION	non-polymer		65.4	2	Chemie (ZN)
7	C, A	GLYCEROL	non-polymer		92.1	2	Chemie (GOL)
8	C, D, A, B	GADOLINIUM ATOM	non-polymer		157.3	4	Chemie (GD)
9	C, D, A, B	CHLORIDE ION	non-polymer		35.5	4	Chemie (CL)
10		water	water		18.0	522	Chemie (HOH)

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	197383.1
Non-Polymers*	Number of molecules	33
	Total formula weight	7665.5
All*	Total formula weight	205048.6

*Water molecules are not included.