5VUA
Pim1 Kinase in complex with a benzofuranone inhibitor
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (B) | Serine/threonine-protein kinase pim-1 | polymer | 298 | 34187.7 | 1 | UniProt (P11309) Pfam (PF00069) | Homo sapiens (Human) | |
| 2 | B (B) | GLYCEROL | non-polymer | 92.1 | 1 | Chemie (GOL) | |||
| 3 | C (B) | PHOSPHATE ION | non-polymer | 95.0 | 1 | Chemie (PO4) | |||
| 4 | D (B) | (2Z)-6-methoxy-7-(piperazin-1-ylmethyl)-2-(1H-pyrrolo[2,3-c]pyridin-3-ylmethylidene)-1-benzofuran-3-one | non-polymer | 390.4 | 1 | Chemie (8GX) | |||
| 5 | E (B) | water | water | 18.0 | 213 | Chemie (HOH) |
Sequence modifications
B: 29 - 313 (UniProt: P11309)
| PDB | External Database | Details |
|---|---|---|
| Met 28 | - | expression tag |
| Ser 314 | - | expression tag |
| Gly 315 | - | expression tag |
| Pro 316 | - | expression tag |
| Ser 317 | - | expression tag |
| Ser 318 | - | expression tag |
| Gly 319 | - | expression tag |
| Glu 320 | - | expression tag |
| Asn 321 | - | expression tag |
| Leu 322 | - | expression tag |
| Tyr 323 | - | expression tag |
| Phe 324 | - | expression tag |
| Gln 325 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 34187.7 | |
| Non-Polymers* | Number of molecules | 3 |
| Total formula weight | 577.5 | |
| All* | Total formula weight | 34765.2 |
