5VTY
Crystal structure of the A/Hong Kong/1/1968 (H3N2) influenza virus hemagglutinin G225Q/L226A mutant in complex with 3'-SLN
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, C, E (A, C, E) | Hemagglutinin HA1 chain | polymer | 323 | 35535.9 | 3 | UniProt (Q91MA7) Pfam (PF00509) | Influenza A virus (strain A/Hong Kong/1/1968 H3N2) | |
| 2 | B, D, F (B, D, F) | Hemagglutinin HA2 chain | polymer | 174 | 20041.1 | 3 | UniProt (Q91MA7) Pfam (PF00509) | Influenza A virus (strain A/Hong Kong/1/1968 H3N2) | |
| 3 | G, M (G, M) | alpha-D-mannopyranose-(1-3)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 748.7 | 2 | In PDB GlyTouCan (G81315DD) | |||
| 4 | H, K, N (H, K, N) | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 424.4 | 3 | In PDB GlyTouCan (G42666HT) | |||
| 5 | I (I) | N-acetyl-alpha-neuraminic acid-(2-3)-beta-D-galactopyranose | branched | 471.4 | 1 | In PDB GlyTouCan (G30207PZ) | |||
| 6 | J (J) | alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 910.8 | 1 | In PDB GlyTouCan (G22768VO) | |||
| 7 | L, O (L, O) | N-acetyl-alpha-neuraminic acid-(2-3)-beta-D-galactopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 674.6 | 2 | In PDB BIRD (PRD_900067) GlyTouCan (G00065MO) | 3'-sialyl-N-acetyllactosamine | ||
| 8 | P, Q, R (A, E) | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 3 | Chemie (NAG) | |||
| 9 | S, T, U, V, W... (A, B, C, D, E...) | water | water | 18.0 | 619 | Chemie (HOH) |
Sequence modifications
A, C, E: 11 - 329 (UniProt: Q91MA7)
B, D, F: 1 - 174 (UniProt: Q91MA7)
| PDB | External Database | Details |
|---|---|---|
| Ala 7 | - | expression tag |
| Asp 8 | - | expression tag |
| Pro 9 | - | expression tag |
| Gly 10 | - | expression tag |
| Gln 225 | Gly 241 | engineered mutation |
| Ala 226 | Leu 242 | engineered mutation |
| PDB | External Database | Details |
|---|---|---|
| Gly 123 | Arg 468 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 6 |
| Total formula weight | 166731.2 | |
| Branched | Number of molecules | 9 |
| Total formula weight | 5502.0 | |
| Non-Polymers* | Number of molecules | 3 |
| Total formula weight | 663.6 | |
| All* | Total formula weight | 172896.9 |
