5VSE
Structure of human G9a SET-domain (EHMT2) in complex with inhibitor 17: N~2~-cyclopentyl-6,7-dimethoxy-N~2~-methyl-N~4~-(1-methylpiperidin-4-yl)quinazoline-2,4-diamine
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Histone-lysine N-methyltransferase EHMT2 | polymer | 275 | 31720.9 | 2 | UniProt (Q96KQ7) Pfam (PF05033) Pfam (PF00856) | Homo sapiens (Human) | Euchromatic histone-lysine N-methyltransferase 2,HLA-B-associated transcript 8,Histone H3-K9 methyltransferase 3,H3-K9-HMTase 3,Lysine N-methyltransferase 1C,Protein G9a |
| 2 | C, D, E, F, I... (A, B) | ZINC ION | non-polymer | 65.4 | 8 | Chemie (ZN) | |||
| 3 | G, M (A, B) | S-ADENOSYLMETHIONINE | non-polymer | 398.4 | 2 | Chemie (SAM) PubChem (5136) PubChem (34755) PubChem (9865603) PubChem (12312798) PubChem (58766358) PubChem (87224684) PubChem (131697735) PubChem (145712080) PubChem (58633578) PubChem (60038769) PubChem (73897310) PubChem (132988922) PubChem (134692588) PubChem (135030730) PubChem (140459785) PubChem (163046094) | |||
| 4 | H, N (A, B) | N~2~-cyclopentyl-6,7-dimethoxy-N~2~-methyl-N~4~-(1-methylpiperidin-4-yl)quinazoline-2,4-diamine | non-polymer | 399.5 | 2 | Chemie (9HG) PubChem (129012137) | |||
| 5 | O, P (A, B) | water | water | 18.0 | 338 | Chemie (HOH) |
Sequence modifications
A, B: 917 - 1190 (UniProt: Q96KQ7)
| PDB | External Database | Details |
|---|---|---|
| Thr 916 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 63441.9 | |
| Non-Polymers* | Number of molecules | 12 |
| Total formula weight | 2119.2 | |
| All* | Total formula weight | 65561.1 |
