5VRX
Human DNA polymerase beta pre-catalytic 8-oxoG:dC extension complex with dTTP bound in Watson-Crick conformation
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | T | DNA (5'-D(*CP*CP*GP*AP*CP*AP*(8OG)P*GP*CP*GP*CP*AP*TP*CP*AP*G)-3') | polymer | 16 | 4909.2 | 1 | synthetic construct | ||
| 2 | P | DNA (5'-D(*CP*TP*GP*AP*TP*GP*CP*GP*CP*C)-3') | polymer | 10 | 3021.0 | 1 | synthetic construct | ||
| 3 | D | DNA (5'-D(P*GP*TP*CP*GP*G)-3') | polymer | 5 | 1536.0 | 1 | synthetic construct | ||
| 4 | A | DNA polymerase beta | polymer | 341 | 39070.5 | 1 | UniProt (P06746) Pfam (PF14716) Pfam (PF10391) Pfam (PF14792) Pfam (PF14791) In PDB | Homo sapiens (Human) | |
| 5 | P, D, A | CALCIUM ION | non-polymer | 40.1 | 5 | Chemie (CA) | |||
| 6 | P | THYMIDINE-5'-TRIPHOSPHATE | non-polymer | 482.2 | 1 | Chemie (TTP) | |||
| 7 | A | IMIDAZOLE | non-polymer | 69.1 | 1 | Chemie (IMD) | |||
| 8 | A | ACETATE ION | non-polymer | 59.0 | 1 | Chemie (ACT) | |||
| 9 | A | DI(HYDROXYETHYL)ETHER | non-polymer | 106.1 | 1 | Chemie (PEG) | |||
| 10 | water | water | 18.0 | 136 | Chemie (HOH) |
Sequence modifications
A: 1 - 335 (UniProt: P06746)
| PDB | External Database | Details |
|---|---|---|
| His 336 | - | expression tag |
| His 337 | - | expression tag |
| His 338 | - | expression tag |
| His 339 | - | expression tag |
| His 340 | - | expression tag |
| His 341 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 48536.7 | |
| Non-Polymers* | Number of molecules | 9 |
| Total formula weight | 916.8 | |
| All* | Total formula weight | 49453.5 |
