5VO2
DLK in complex with inhibitor 5-(1-isopropyl-5-(1-(oxetan-3-yl)piperidin-4-yl)-1H-pyrazol-3-yl)-3-(trifluoromethyl)pyridin-2-amine (compound 7)
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Mitogen-activated protein kinase kinase kinase 12 | polymer | 300 | 34018.0 | 1 | UniProt (Q12852) Pfam (PF07714) | Homo sapiens (Human) | Dual leucine zipper bearing kinase,DLK,Leucine-zipper protein kinase,ZPK,MAPK-upstream kinase,MUK,Mixed lineage kinase |
| 2 | B (A) | 5-{5-[1-(oxetan-3-yl)piperidin-4-yl]-1-(propan-2-yl)-1H-pyrazol-3-yl}-3-(trifluoromethyl)pyridin-2-amine | non-polymer | 409.4 | 1 | Chemie (9FV) | |||
| 3 | C (A) | water | water | 18.0 | 35 | Chemie (HOH) |
Sequence modifications
A: 115 - 402 (UniProt: Q12852)
| PDB | External Database | Details |
|---|---|---|
| Met 112 | - | initiating methionine |
| Gly 113 | - | expression tag |
| Ser 114 | - | expression tag |
| Gly 403 | - | expression tag |
| Asn 404 | - | expression tag |
| Ser 405 | - | expression tag |
| His 406 | - | expression tag |
| His 407 | - | expression tag |
| His 408 | - | expression tag |
| His 409 | - | expression tag |
| His 410 | - | expression tag |
| His 411 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 34018.0 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 409.4 | |
| All* | Total formula weight | 34427.5 |
