5VO1

DLK in complex with compound 10 (5-(1-isopropyl-5-(3-(oxetan-3-yl)-3-azabicyclo[3.1.0]hexan-6-yl)-1H-pyrazol-3-yl)-3-(trifluoromethyl)pyridin-2-amine)

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A	Mitogen-activated protein kinase kinase kinase 12	polymer	300	34018.0	1	UniProt (Q12852) Pfam (PF07714) In PDB	Homo sapiens (Human)	Dual leucine zipper bearing kinase,DLK,Leucine-zipper protein kinase,ZPK,MAPK-upstream kinase,MUK,Mixed lineage kinase
2	A	5-{5-[(1R,5S,6r)-3-(oxetan-3-yl)-3-azabicyclo[3.1.0]hexan-6-yl]-1-(propan-2-yl)-1H-pyrazol-3-yl}-3-(trifluoromethyl)pyridin-2-amine	non-polymer		407.4	1	Chemie (9FS)
3		water	water		18.0	151	Chemie (HOH)

Sequence modifications

A: 115 - 402 (UniProt: Q12852)

PDB	External Database	Details
Met 112	-	initiating methionine
Gly 113	-	expression tag
Ser 114	-	expression tag
Gly 403	-	expression tag
Asn 404	-	expression tag
Ser 405	-	expression tag
His 406	-	expression tag
His 407	-	expression tag
His 408	-	expression tag
His 409	-	expression tag
His 410	-	expression tag
His 411	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	1
	Total formula weight	34018.0
Non-Polymers*	Number of molecules	1
	Total formula weight	407.4
All*	Total formula weight	34425.5

*Water molecules are not included.