5VJ6

BG505 SOSIP.664 in complex with broadly neutralizing antibodies PG9 and 8ANC195

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C	Envelope glycoprotein gp160	polymer	153	17146.5	3	UniProt (Q2N0S6) Pfam (PF00517) In PDB	Human immunodeficiency virus 1
2	D, E, F	Envelope glycoprotein gp160	polymer	481	54064.3	3	UniProt (Q2N0S6) Pfam (PF00516) In PDB	Human immunodeficiency virus 1
3	H	PG9 Fab heavy chain	polymer	248	27211.2	1	UniProt (P0DOX5) Pfam (PF07686) Pfam (PF07654) In PDB	Homo sapiens (Human)
4	M, O, Q	8ANC195 Fab heavy chain	polymer	233	24788.8	3	UniProt (S6B291) Pfam (PF07686) Pfam (PF07654) In PDB	Homo sapiens (Human)
5	N, P, R	8ANC195 Fab light chain	polymer	215	23460.0	3	UniProt (Q8TCD0) Pfam (PF07686) Pfam (PF07654) In PDB	Homo sapiens (Human)
6	L	PG9 Fab light chain	polymer	216	22837.3	1	UniProt (Q6GMW3) Pfam (PF07686) Pfam (PF07654) In PDB	Homo sapiens (Human)

Sequence modifications

A, B, C: 512 - 664 (UniProt: Q2N0S6)

PDB	External Database	Details
Pro 559	Ile 556	engineered mutation
Cys 605	Thr 602	engineered mutation

D, E, F: 31 - 508 (UniProt: Q2N0S6)

PDB	External Database	Details
Asn 332	Thr 330	engineered mutation
Cys 501	Ala 498	engineered mutation
Arg 509	-	expression tag
Arg 510	-	expression tag
Arg 511	-	expression tag
Arg 512	-	expression tag
Arg 513	-	expression tag

H: 2 - 130 (PDB: 5VJ6)
H: 131 - 238 (UniProt: P0DOX5)
L: 1 - 100 (PDB: 5VJ6)
L: 101 - 212 (UniProt: Q6GMW3)
M, O, Q: 1 - 113 (PDB: 5VJ6)
M, O, Q: 114 - 214 (UniProt: S6B291)
N, P, R: 1 - 106 (PDB: 5VJ6)
N, P, R: 107 - 214 (UniProt: Q8TCD0)

Contents of the asymmetric unit

Polymers	Number of chains	14
	Total formula weight	408427.3
All*	Total formula weight	408427.3

*Water molecules are not included.