5VIY

BG505 SOSIP.664 in complex with broadly neutralizing antibodies BG1 and 8ANC195

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C (A, B, C)	Envelope glycoprotein gp160	polymer	153	17146.5	3	UniProt (Q2N0S6) Pfam (PF00517)	Human immunodeficiency virus 1
2	D, E, F (D, E, F)	Envelope glycoprotein gp160	polymer	481	54064.3	3	UniProt (Q2N0S6) Pfam (PF00516)	Human immunodeficiency virus 1
3	G, I (G, I)	BG1 Fab light chain	polymer	214	23527.1	2	UniProt (P01834) Pfam (PF07654)	Homo sapiens (Human)
4	H, J (H, J)	BG1 Fab heavy chain	polymer	233	24931.9	2	UniProt (S6B291) Pfam (PF07686) Pfam (PF07654)	Homo sapiens (Human)
5	K, M, O (K, M, O)	8ANC195 G52K5 Fab heavy chain	polymer	233	24788.8	3	UniProt (S6B291) Pfam (PF07686) Pfam (PF07654)	Homo sapiens (Human)
6	L, N, P (L, N, P)	8ANC195 G52K5 Fab light chain	polymer	215	23460.0	3	UniProt (Q8TCD0) Pfam (PF07654) Pfam (PF07686)	Homo sapiens (Human)
7	AB, HB, NA, Q, R... (0, 7, n, Q, R...)	alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		910.8	9	In PDB GlyTouCan (G22768VO)
8	AA, BB, CA, CB, DB... (a, 1, c, 2, 3...)	2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		424.4	18	In PDB GlyTouCan (G42666HT)
9	LA, W, YA (l, W, y)	alpha-D-mannopyranose-(1-3)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		748.7	3	In PDB GlyTouCan (G81315DD)
10	MA, X, ZA (m, X, z)	alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)-alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		1235.1	3	In PDB GlyTouCan (G23799GS)
11	BA, Y (b, Y)	alpha-D-mannopyranose-(1-6)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		748.7	2	In PDB GlyTouCan (G22573RC)
12	DA, EB, FA, FB, GB... (d, 4, f, 5, 6...)	beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		586.5	7	In PDB GlyTouCan (G15407YE)
13	SA (s)	alpha-L-fucopyranose-(1-6)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		367.3	1	In PDB GlyTouCan (G86851RC)
14	TA (t)	alpha-D-mannopyranose-(1-3)-alpha-D-mannopyranose-(1-6)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		910.8	1	In PDB GlyTouCan (G10756ZZ)
15	IB, JB, KB, LB, MB... (A, B, C, D, E...)	2-acetamido-2-deoxy-beta-D-glucopyranose	non-polymer		221.2	13	Chemie (NAG)

Sequence modifications

A, B, C: 512 - 664 (UniProt: Q2N0S6)

PDB	External Database	Details
Pro 559	Ile 556	conflict
Cys 605	Thr 602	conflict

D, E, F: 31 - 511 (UniProt: Q2N0S6)

PDB	External Database	Details
Asn 332	Thr 330	conflict
Cys 501	Ala 498	conflict
Arg 509	Glu 506	conflict
Arg 510	Lys 507	conflict
Arg 512	-	expression tag
Arg 513	-	expression tag

G, I: 1 - 107 (PDB: 5VIY)
G, I: 108 - 214 (UniProt: P01834)
H, J: 1 - 133 (PDB: 5VIY)
H, J: 134 - 233 (UniProt: S6B291)
K, M, O: 1 - 113 (PDB: 5VIY)
K, M, O: 114 - 214 (UniProt: S6B291)
L, N, P: 1 - 106 (PDB: 5VIY)
L, N, P: 107 - 214 (UniProt: Q8TCD0)

Contents of the asymmetric unit

Polymers	Number of chains	16
	Total formula weight	455296.8
Branched	Number of molecules	44
	Total formula weight	28669.3
Non-Polymers*	Number of molecules	13
	Total formula weight	2875.7
All*	Total formula weight	486841.8

*Water molecules are not included.