5VIL

Crystal structure of ASK1 kinase domain with a potent inhibitor (analog 6)

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C, D (A, B, C, D)	Mitogen-activated protein kinase kinase kinase 5	polymer	293	32979.6	4	UniProt (Q99683) Pfam (PF00069)	Homo sapiens (Human)	Apoptosis signal-regulating kinase 1,ASK-1,MAPK/ERK kinase kinase 5,MEKK 5
2	E, G, K, L (A, B, C, D)	2-methoxy-N-{6-[4-(propan-2-yl)-4H-1,2,4-triazol-3-yl]pyridin-2-yl}-5-sulfamoylbenzamide	non-polymer		416.5	4	Chemie (9E1)
3	F, H, I, J (A, B)	DIMETHYL SULFOXIDE	non-polymer		78.1	4	Chemie (DMS)
4	M, N, O, P (A, B, C, D)	water	water		18.0	138	Chemie (HOH)

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	131918.5
Non-Polymers*	Number of molecules	8
	Total formula weight	1978.3
All*	Total formula weight	133896.8

*Water molecules are not included.