5VGI
Crystal Structure of KDM4 with the Small Molecule Inhibitor QC6352
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, B, C, D | Lysine-specific demethylase 4A | polymer | 370 | 43138.0 | 4 | UniProt (O75164) Pfam (PF02375) Pfam (PF02373) In PDB | Homo sapiens (Human) | JmjC domain-containing histone demethylation protein 3A,Jumonji domain-containing protein 2A |
2 | A, B, C, D | NICKEL (II) ION | non-polymer | 58.7 | 4 | Chemie (NI) | |||
3 | A, B, C, D | ZINC ION | non-polymer | 65.4 | 4 | Chemie (ZN) | |||
4 | A, B, C, D | 3-[({(1R)-6-[methyl(phenyl)amino]-1,2,3,4-tetrahydronaphthalen-1-yl}methyl)amino]pyridine-4-carboxylic acid | non-polymer | 387.5 | 4 | Chemie (9DJ) | |||
5 | water | water | 18.0 | 243 | Chemie (HOH) |
Sequence modifications
A, B, C, D: 5 - 354 (UniProt: O75164)
PDB | External Database | Details |
---|---|---|
Met -15 | - | expression tag |
Gly -14 | - | expression tag |
His -13 | - | expression tag |
His -12 | - | expression tag |
His -11 | - | expression tag |
His -10 | - | expression tag |
His -9 | - | expression tag |
His -8 | - | expression tag |
His -7 | - | expression tag |
His -6 | - | expression tag |
Gly -5 | - | expression tag |
Ser -4 | - | expression tag |
Gly -3 | - | expression tag |
Glu -2 | - | expression tag |
Asn -1 | - | expression tag |
Leu 0 | - | expression tag |
Tyr 1 | - | expression tag |
Phe 2 | - | expression tag |
Gln 3 | - | expression tag |
Ser 4 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 4 |
Total formula weight | 172551.8 | |
Non-Polymers* | Number of molecules | 12 |
Total formula weight | 2046.3 | |
All* | Total formula weight | 174598.1 |