5VFU
Nucleotide-driven Triple-state Remodeling of the AAA-ATPase Channel in the Activated Human 26S Proteasome
This is a non-PDB format compatible entry.
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (U) | 26S proteasome non-ATPase regulatory subunit 1 | polymer | 911 | 101263.2 | 1 | UniProt (Q99460) Pfam (PF21505) Pfam (PF01851) Pfam (PF13646) Pfam (PF18004) | Homo sapiens (Human) | 26S proteasome regulatory subunit RPN2, 26S proteasome regulatory subunit S1, 26S proteasome subunit p112, Rpn2 |
| 2 | B (V) | 26S proteasome non-ATPase regulatory subunit 3 | polymer | 480 | 54755.7 | 1 | UniProt (O43242) Pfam (PF01399) Pfam (PF08375) | Homo sapiens (Human) | 26S proteasome regulatory subunit RPN3, 26S proteasome regulatory subunit S3, Proteasome subunit p58, Rpn3 |
| 3 | C (W) | 26S proteasome non-ATPase regulatory subunit 12 | polymer | 456 | 52979.4 | 1 | UniProt (O00232) Pfam (PF22241) Pfam (PF01399) Pfam (PF18098) | Homo sapiens (Human) | 26S proteasome regulatory subunit RPN5, 26S proteasome regulatory subunit p55, Rpn5 |
| 4 | D (X) | 26S proteasome non-ATPase regulatory subunit 11 | polymer | 380 | 42868.6 | 1 | UniProt (O00231) Pfam (PF18055) Pfam (PF01399) Pfam (PF18503) | Homo sapiens (Human) | 26S proteasome regulatory subunit RPN6, 26S proteasome regulatory subunit S9, 26S proteasome regulatory subunit p44.5, Rpn6 |
| 5 | E (Y) | 26S proteasome non-ATPase regulatory subunit 6 | polymer | 378 | 44336.9 | 1 | UniProt (Q15008) Pfam (PF10602) Pfam (PF01399) Pfam (PF21154) | Homo sapiens (Human) | 26S proteasome regulatory subunit RPN7, 26S proteasome regulatory subunit S10, Breast cancer-associated protein SGA-113M, Phosphonoformate immuno-associated protein 4, Proteasome regulatory particle subunit p44S10, p42A, Rpn7 |
| 6 | F (Z) | 26S proteasome non-ATPase regulatory subunit 7 | polymer | 286 | 32382.1 | 1 | UniProt (P51665) Pfam (PF01398) Pfam (PF13012) | Homo sapiens (Human) | 26S proteasome regulatory subunit RPN8,26S proteasome regulatory subunit S12,Mov34 protein homolog,Proteasome subunit p40 |
| 7 | G (a) | 26S proteasome non-ATPase regulatory subunit 13 | polymer | 373 | 42592.9 | 1 | UniProt (Q9UNM6) Pfam (PF22037) Pfam (PF01399) | Homo sapiens (Human) | 26S proteasome non-ATPase regulatory subunit 13 Synonyms: 26S proteasome regulatory subunit RPN9, 26S proteasome regulatory subunit S11, 26S proteasome regulatory subunit p40.5, Rpn9 |
| 8 | H (b) | 26S proteasome non-ATPase regulatory subunit 4 | polymer | 191 | 20866.0 | 1 | UniProt (P55036) Pfam (PF13519) | Homo sapiens (Human) | 26S proteasome regulatory subunit RPN10, 26S proteasome regulatory subunit S5A, Antisecretory factor 1, ASF, Multiubiquitin chain-binding protein, Rpn10 |
| 9 | I (c) | 26S proteasome non-ATPase regulatory subunit 14 | polymer | 287 | 32329.4 | 1 | UniProt (O00487) Pfam (PF01398) | Homo sapiens (Human) | 26S proteasome regulatory subunit RPN11, 26S proteasome-associated PAD1 homolog 1, Rpn11 |
| 10 | J (d) | 26S proteasome non-ATPase regulatory subunit 8 | polymer | 257 | 30039.7 | 1 | UniProt (P48556) Pfam (PF10075) | Homo sapiens (Human) | 26S proteasome regulatory subunit RPN12, 26S proteasome regulatory subunit S14, p31, Rpn12 |
| 11 | K (e) | Sem1 | polymer | 70 | 8284.6 | 1 | Homo sapiens (Human) | ||
| 12 | L (A) | 26S protease regulatory subunit 7 | polymer | 361 | 40494.7 | 1 | UniProt (P35998) Pfam (PF21236) Pfam (PF00004) Pfam (PF17862) | Homo sapiens (Human) | 26S proteasome AAA-ATPase subunit RPT1, Proteasome 26S subunit ATPase 2, Protein MSS1, Rpt1 |
| 13 | M (B) | 26S protease regulatory subunit 4 | polymer | 348 | 38799.3 | 1 | UniProt (P62191) Pfam (PF16450) Pfam (PF00004) Pfam (PF17862) | Homo sapiens (Human) | P26s4,26S proteasome AAA-ATPase subunit RPT2, Proteasome 26S subunit ATPase 1, Rpt2 |
| 14 | N (C) | 26S protease regulatory subunit 8 | polymer | 384 | 43114.0 | 1 | UniProt (P62195) Pfam (PF16450) Pfam (PF00004) Pfam (PF17862) | Homo sapiens (Human) | 26S proteasome AAA-ATPase subunit RPT6, Proteasome 26S subunit ATPase 5, Proteasome subunit p45, Thyroid hormone receptor-interacting protein 1, TRIP1, p45/SUG, Rpt6 |
| 15 | O (D) | 26S protease regulatory subunit 6B | polymer | 380 | 43303.5 | 1 | UniProt (P43686) Pfam (PF16450) Pfam (PF00004) Pfam (PF17862) | Homo sapiens (Human) | 26S proteasome AAA-ATPase subunit RPT3, MB67-interacting protein, MIP224, Proteasome 26S subunit ATPase 4, Tat-binding protein 7, TBP-7, Rpt3 |
| 16 | P (E) | 26S protease regulatory subunit 10B | polymer | 353 | 39840.9 | 1 | UniProt (P62333) Pfam (PF16450) Pfam (PF00004) Pfam (PF17862) | Homo sapiens (Human) | 26S proteasome AAA-ATPase subunit RPT4, Proteasome 26S subunit ATPase 6, Proteasome subunit p42, Rpt4 |
| 17 | Q (F) | 26S protease regulatory subunit 6A | polymer | 377 | 42104.2 | 1 | UniProt (P17980) Pfam (PF16450) Pfam (PF00004) Pfam (PF17862) | Homo sapiens (Human) | 26S proteasome AAA-ATPase subunit RPT5, Proteasome 26S subunit ATPase 3, Proteasome subunit P50, Tat-binding protein 1, TBP-1, Rpt5 |
| 18 | FA, R (G, g) | Proteasome subunit alpha type-6 | polymer | 240 | 26727.7 | 2 | UniProt (P60900) Pfam (PF10584) Pfam (PF00227) | Homo sapiens (Human) | 27 kDa prosomal protein, p27K, Macropain iota chain, Multicatalytic endopeptidase complex iota chain, Proteasome iota chain, alpha1 |
| 19 | GA, S (H, h) | Proteasome subunit alpha type-2 | polymer | 232 | 25725.3 | 2 | UniProt (P25787) Pfam (PF10584) Pfam (PF00227) | Homo sapiens (Human) | Macropain subunit C3, Multicatalytic endopeptidase complex subunit C3, Proteasome component C3, alpha2 |
| 20 | HA, T (I, i) | Proteasome subunit alpha type-4 | polymer | 250 | 28118.2 | 2 | UniProt (P25789) Pfam (PF10584) Pfam (PF00227) | Homo sapiens (Human) | Macropain subunit C9, Multicatalytic endopeptidase complex subunit C9, Proteasome component C9, Proteasome subunit L, alpha3 |
| 21 | IA, U (J, j) | Proteasome subunit alpha type-7 | polymer | 243 | 27382.2 | 2 | UniProt (O14818) Pfam (PF10584) Pfam (PF00227) | Homo sapiens (Human) | Proteasome subunit RC6-1, Proteasome subunit XAPC7, alpha4 |
| 22 | JA, V (K, k) | Proteasome subunit alpha type-5 | polymer | 234 | 25570.0 | 2 | UniProt (P28066) Pfam (PF10584) Pfam (PF00227) | Homo sapiens (Human) | Macropain zeta chain, Multicatalytic endopeptidase complex zeta chain, Proteasome zeta chain, alpha5 |
| 23 | KA, W (L, l) | Proteasome subunit alpha type-1 | polymer | 238 | 26728.4 | 2 | UniProt (P25786) Pfam (PF10584) Pfam (PF00227) | Homo sapiens (Human) | 30 kDa prosomal protein, PROS-30, Macropain subunit C2, Multicatalytic endopeptidase complex subunit C2, Proteasome component C2, Proteasome nu chain, alpha6 |
| 24 | LA, X (M, m) | Proteasome subunit alpha type-3 | polymer | 245 | 27287.1 | 2 | UniProt (P25788) Pfam (PF10584) Pfam (PF00227) | Homo sapiens (Human) | Macropain subunit C8, Multicatalytic endopeptidase complex subunit C8, Proteasome component C8, alpha7 |
| 25 | MA, Y (N, n) | Proteasome subunit beta type-6 | polymer | 191 | 20471.1 | 2 | UniProt (P28072) Pfam (PF00227) | Homo sapiens (Human) | Macropain delta chain, Multicatalytic endopeptidase complex delta chain, Proteasome delta chain, Proteasome subunit Y, beta1 |
| 26 | NA, Z (O, o) | Proteasome subunit beta type-7 | polymer | 220 | 23745.3 | 2 | UniProt (Q99436) Pfam (PF00227) Pfam (PF12465) | Homo sapiens (Human) | Macropain chain Z, Multicatalytic endopeptidase complex chain Z, Proteasome subunit Z, beta2 |
| 27 | AA, OA (P, p) | Proteasome subunit beta type-3 | polymer | 204 | 22841.7 | 2 | UniProt (P49720) Pfam (PF00227) | Homo sapiens (Human) | Proteasome chain 13, Proteasome component C10-II, Proteasome theta chain, beta3 |
| 28 | BA, PA (Q, q) | Proteasome subunit beta type-2 | polymer | 199 | 22720.1 | 2 | UniProt (P49721) Pfam (PF00227) | Homo sapiens (Human) | Macropain subunit C7-I, Multicatalytic endopeptidase complex subunit C7-I, Proteasome component C7-I, beta4 |
| 29 | CA, QA (R, r) | Proteasome subunit beta type-5 | polymer | 201 | 22199.1 | 2 | UniProt (P28074) Pfam (PF00227) | Homo sapiens (Human) | Macropain epsilon chain, Multicatalytic endopeptidase complex epsilon chain, Proteasome chain 6, Proteasome epsilon chain, Proteasome subunit MB1, Proteasome subunit X, beta5 |
| 30 | DA, RA (S, s) | Proteasome subunit beta type-1 | polymer | 213 | 23579.0 | 2 | UniProt (P20618) Pfam (PF00227) | Homo sapiens (Human) | Macropain subunit C5, Multicatalytic endopeptidase complex subunit C5, Proteasome component C5, Proteasome gamma chain, beta6 |
| 31 | EA, SA (T, t) | Proteasome subunit beta type-4 | polymer | 215 | 23994.3 | 2 | UniProt (P28070) Pfam (PF00227) | Homo sapiens (Human) | 26 kDa prosomal protein, PROS-26, Macropain beta chain, Multicatalytic endopeptidase complex beta chain, Proteasome beta chain, Proteasome chain 3, HsN3, beta7 |
| 32 | TA (f) | 26S proteasome non-ATPase regulatory subunit 2 | polymer | 908 | 100313.6 | 1 | UniProt (Q13200) Pfam (PF17781) Pfam (PF01851) Pfam (PF18051) | Homo sapiens (Human) | 26S proteasome regulatory subunit RPN1, 26S proteasome regulatory subunit S2, 26S proteasome subunit p97, Protein 55.11, Tumor necrosis factor type 1 receptor-associated protein 2, Rpn1 |
| 33 | UA (c) | ZINC ION | non-polymer | 65.4 | 1 | Chemie (ZN) |
Sequence modifications
a: 4 - 376 (UniProt: Q9UNM6)
| PDB | External Database | Details |
|---|---|---|
| Ser 13 | Asn 13 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 46 |
| Total formula weight | 1504847.3 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 65.4 | |
| All* | Total formula weight | 1504912.7 |
