5VEB

Crystal structure of a Fab binding to extracellular domain 5 of Cadherin-6

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A	anti-CDH6 Fab heavy chain	polymer	225	23823.5	1	UniProt (S6B291) Pfam (PF07686) Pfam (PF07654) In PDB	Homo sapiens (Human)
2	B, L	anti-CDH6 Fab light chain	polymer	215	23380.9	2	UniProt (P01834) Pfam (PF07654) In PDB	Homo sapiens (Human)
3	H	anti-CDH6 Fab heavy chain	polymer	225	23724.4	1	UniProt (S6B291) Pfam (PF07686) Pfam (PF07654) In PDB	Homo sapiens (Human)
4	X, Y	Cadherin-6	polymer	125	13907.4	2	UniProt (P55285) Pfam (PF00028) In PDB	Homo sapiens (human)	Kidney cadherin,K-cadherin
5	X, Y	2-acetamido-2-deoxy-alpha-D-galactopyranose	non-polymer		221.2	4	Chemie (A2G)
6		water	water		18.0	241	Chemie (HOH)

Sequence modifications

A: 1 - 107 (PDB: 5VEB)
A: 108 - 225 (UniProt: S6B291)
B, L: 1 - 108 (PDB: 5VEB)
B, L: 109 - 215 (UniProt: P01834)
H: 1 - 107 (PDB: 5VEB)
H: 108 - 225 (UniProt: S6B291)
X, Y: 490 - 608 (UniProt: P55285)

PDB	External Database	Details
Leu 609	-	expression tag
Glu 610	-	expression tag
Val 611	-	expression tag
Leu 612	-	expression tag
Phe 613	-	expression tag
Gln 614	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	6
	Total formula weight	122124.5
Non-Polymers*	Number of molecules	4
	Total formula weight	884.8
All*	Total formula weight	123009.4

*Water molecules are not included.