5VCZ
CRYSTAL STRUCTURE OF HUMAN MYT1 KINASE DOMAIN IN COMPLEX WITH Bosutinib isomer
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A | Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase | polymer | 311 | 34498.1 | 1 | UniProt (Q99640) Pfam (PF00069) In PDB | Homo sapiens (Human) | Myt1 kinase |
2 | A | 4-[(3,5-DICHLORO-4-METHOXYPHENYL)AMINO]-6-METHOXY-7-[3-(4-METHYLPIPERAZIN-1-YL)PROPOXY]QUINOLINE-3-CARBONITRILE | non-polymer | 530.4 | 1 | Chemie (XZN) | |||
3 | A | 1,2-ETHANEDIOL | non-polymer | 62.1 | 5 | Chemie (EDO) | |||
4 | A | DI(HYDROXYETHYL)ETHER | non-polymer | 106.1 | 1 | Chemie (PEG) | |||
5 | water | water | 18.0 | 236 | Chemie (HOH) |
Sequence modifications
A: 75 - 362 (UniProt: Q99640)
PDB | External Database | Details |
---|---|---|
Met -22 | - | initiating methionine |
His -21 | - | expression tag |
His -20 | - | expression tag |
His -19 | - | expression tag |
His -18 | - | expression tag |
His -17 | - | expression tag |
His -16 | - | expression tag |
Ser -15 | - | expression tag |
Ser -14 | - | expression tag |
Gly -13 | - | expression tag |
Val -12 | - | expression tag |
Asp -11 | - | expression tag |
Leu -10 | - | expression tag |
Gly -9 | - | expression tag |
Thr -8 | - | expression tag |
Glu -7 | - | expression tag |
Asn -6 | - | expression tag |
Leu -5 | - | expression tag |
Tyr -4 | - | expression tag |
Phe -3 | - | expression tag |
Gln -2 | - | expression tag |
Ser -1 | - | expression tag |
Met 74 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 1 |
Total formula weight | 34498.1 | |
Non-Polymers* | Number of molecules | 7 |
Total formula weight | 946.9 | |
All* | Total formula weight | 35445.0 |