5VCX
CRYSTAL STRUCTURE OF HUMAN MYT1 KINASE DOMAIN (UNTREATED) IN COMPLEX WITH SARACATINIB
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A | Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase | polymer | 311 | 34498.1 | 1 | UniProt (Q99640) Pfam (PF00069) In PDB | Homo sapiens (Human) | Myt1 kinase |
2 | A | N-(5-CHLORO-1,3-BENZODIOXOL-4-YL)-7-[2-(4-METHYLPIPERAZIN-1-YL)ETHOXY]-5-(TETRAHYDRO-2H-PYRAN-4-YLOXY)QUINAZOLIN-4-AMINE | non-polymer | 542.0 | 1 | Chemie (H8H) | |||
3 | A | 1,2-ETHANEDIOL | non-polymer | 62.1 | 1 | Chemie (EDO) | |||
4 | water | water | 18.0 | 32 | Chemie (HOH) |
Sequence modifications
A: 75 - 362 (UniProt: Q99640)
PDB | External Database | Details |
---|---|---|
Met 52 | - | initiating methionine |
His 53 | - | expression tag |
His 54 | - | expression tag |
His 55 | - | expression tag |
His 56 | - | expression tag |
His 57 | - | expression tag |
His 58 | - | expression tag |
Ser 59 | - | expression tag |
Ser 60 | - | expression tag |
Gly 61 | - | expression tag |
Val 62 | - | expression tag |
Asp 63 | - | expression tag |
Leu 64 | - | expression tag |
Gly 65 | - | expression tag |
Thr 66 | - | expression tag |
Glu 67 | - | expression tag |
Asn 68 | - | expression tag |
Leu 69 | - | expression tag |
Tyr 70 | - | expression tag |
Phe 71 | - | expression tag |
Gln 72 | - | expression tag |
Ser 73 | - | expression tag |
Met 74 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 1 |
Total formula weight | 34498.1 | |
Non-Polymers* | Number of molecules | 2 |
Total formula weight | 604.1 | |
All* | Total formula weight | 35102.2 |