5VCW
CRYSTAL STRUCTURE OF HUMAN MYT1 KINASE DOMAIN IN COMPLEX WITH Pelitinib
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, B | Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase | polymer | 311 | 34498.1 | 2 | UniProt (Q99640) Pfam (PF00069) In PDB | Homo sapiens (Human) | Myt1 kinase |
2 | A, B | (2E)-N-{4-[(3-chloro-4-fluorophenyl)amino]-3-cyano-7-ethoxyquinolin-6-yl}-4-(dimethylamino)but-2-enamide | non-polymer | 467.9 | 2 | Chemie (93J) | |||
3 | A, B | SULFATE ION | non-polymer | 96.1 | 5 | Chemie (SO4) | |||
4 | A, B | 1,2-ETHANEDIOL | non-polymer | 62.1 | 4 | Chemie (EDO) | |||
5 | water | water | 18.0 | 52 | Chemie (HOH) |
Sequence modifications
A, B: 75 - 362 (UniProt: Q99640)
PDB | External Database | Details |
---|---|---|
Met 52 | - | initiating methionine |
His 53 | - | expression tag |
His 54 | - | expression tag |
His 55 | - | expression tag |
His 56 | - | expression tag |
His 57 | - | expression tag |
His 58 | - | expression tag |
Ser 59 | - | expression tag |
Ser 60 | - | expression tag |
Gly 61 | - | expression tag |
Val 62 | - | expression tag |
Asp 63 | - | expression tag |
Leu 64 | - | expression tag |
Gly 65 | - | expression tag |
Thr 66 | - | expression tag |
Glu 67 | - | expression tag |
Asn 68 | - | expression tag |
Leu 69 | - | expression tag |
Tyr 70 | - | expression tag |
Phe 71 | - | expression tag |
Gln 72 | - | expression tag |
Ser 73 | - | expression tag |
Met 74 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 2 |
Total formula weight | 68996.3 | |
Non-Polymers* | Number of molecules | 11 |
Total formula weight | 1664.4 | |
All* | Total formula weight | 70660.7 |