5VCD
Crystal structure of the cysteine depleted CYP3A4 bound to glycerol
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Cytochrome P450 3A4 | polymer | 487 | 55671.6 | 1 | UniProt (P08684) Pfam (PF00067) | Homo sapiens (Human) | 1,8-cineole 2-exo-monooxygenase,Albendazole monooxygenase,Albendazole sulfoxidase,CYPIIIA3,CYPIIIA4,Cholesterol 25-hydroxylase,Cytochrome P450 3A3,Cytochrome P450 HLp,Cytochrome P450 NF-25,Cytochrome P450-PCN1,Nifedipine oxidase,Quinine 3-monooxygenase,Taurochenodeoxycholate 6-alpha-hydroxylase |
| 2 | B (A) | PROTOPORPHYRIN IX CONTAINING FE | non-polymer | 616.5 | 1 | Chemie (HEM) | |||
| 3 | C, D, E, F, G... (A) | GLYCEROL | non-polymer | 92.1 | 12 | Chemie (GOL) | |||
| 4 | O (A) | water | water | 18.0 | 106 | Chemie (HOH) |
Sequence modifications
A: 23 - 503 (UniProt: P08684)
| PDB | External Database | Details |
|---|---|---|
| Met 1 | - | SEE REMARK 999 |
| Ala 2 | - | SEE REMARK 999 |
| Ala 58 | Cys 58 | engineered mutation |
| Met 64 | Cys 64 | engineered mutation |
| Ala 98 | Cys 98 | engineered mutation |
| Thr 239 | Cys 239 | engineered mutation |
| Ala 377 | Cys 377 | engineered mutation |
| Ser 468 | Cys 468 | engineered mutation |
| His 504 | - | expression tag |
| His 505 | - | expression tag |
| His 506 | - | expression tag |
| His 507 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 55671.6 | |
| Non-Polymers* | Number of molecules | 13 |
| Total formula weight | 1721.6 | |
| All* | Total formula weight | 57393.2 |
