5VC6
crystal structure of human WEE1 kinase domain in complex with PHA-848125
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Wee1-like protein kinase | polymer | 289 | 32440.9 | 1 | UniProt (P30291) Pfam (PF00069) | Homo sapiens (Human) | WEE1hu,Wee1A kinase |
| 2 | B (A) | N,1,4,4-TETRAMETHYL-8-{[4-(4-METHYLPIPERAZIN-1-YL)PHENYL]AMINO}-4,5-DIHYDRO-1H-PYRAZOLO[4,3-H]QUINAZOLINE-3-CARBOXAMIDE | non-polymer | 460.6 | 1 | Chemie (P48) | |||
| 3 | C (A) | 1,2-ETHANEDIOL | non-polymer | 62.1 | 1 | Chemie (EDO) | |||
| 4 | D (A) | water | water | 18.0 | 94 | Chemie (HOH) |
Sequence modifications
A: 291 - 575 (UniProt: P30291)
| PDB | External Database | Details |
|---|---|---|
| Gly 287 | - | expression tag |
| Ala 288 | - | expression tag |
| Gly 289 | - | expression tag |
| Ser 290 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 32440.9 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 522.6 | |
| All* | Total formula weight | 32963.5 |
