5VC5
Crystal structure of human WEE1 kinase domain in complex with PD-166285
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A | Wee1-like protein kinase | polymer | 289 | 32440.9 | 1 | UniProt (P30291) Pfam (PF00069) In PDB | Homo sapiens (Human) | WEE1hu,Wee1A kinase |
| 2 | A | 6-(2,6-dichlorophenyl)-2-({4-[2-(diethylamino)ethoxy]phenyl}amino)-8-methylpyrido[2,3-d]pyrimidin-7(8H)-one | non-polymer | 512.4 | 1 | Chemie (96M) | |||
| 3 | A | 1,2-ETHANEDIOL | non-polymer | 62.1 | 1 | Chemie (EDO) | |||
| 4 | A | CHLORIDE ION | non-polymer | 35.5 | 2 | Chemie (CL) | |||
| 5 | A | DI(HYDROXYETHYL)ETHER | non-polymer | 106.1 | 1 | Chemie (PEG) | |||
| 6 | water | water | 18.0 | 84 | Chemie (HOH) |
Sequence modifications
A: 291 - 575 (UniProt: P30291)
| PDB | External Database | Details |
|---|---|---|
| Gly 287 | - | expression tag |
| Ala 288 | - | expression tag |
| Gly 289 | - | expression tag |
| Ser 290 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 32440.9 | |
| Non-Polymers* | Number of molecules | 5 |
| Total formula weight | 751.5 | |
| All* | Total formula weight | 33192.4 |
