5VC3
CRYSTAL STRUCTURE OF HUMAN WEE1 KINASE DOMAIN IN COMPLEX WITH BOSUTINIB
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Wee1-like protein kinase | polymer | 289 | 32440.9 | 1 | UniProt (P30291) Pfam (PF00069) | Homo sapiens (Human) | WEE1hu,Wee1A kinase |
| 2 | B (A) | 4-[(2,4-dichloro-5-methoxyphenyl)amino]-6-methoxy-7-[3-(4-methylpiperazin-1-yl)propoxy]quinoline-3-carbonitrile | non-polymer | 530.4 | 1 | Chemie (DB8) | |||
| 3 | C, D, E, F (A) | 1,2-ETHANEDIOL | non-polymer | 62.1 | 4 | Chemie (EDO) | |||
| 4 | G (A) | CHLORIDE ION | non-polymer | 35.5 | 1 | Chemie (CL) | |||
| 5 | H (A) | water | water | 18.0 | 72 | Chemie (HOH) |
Sequence modifications
A: 291 - 575 (UniProt: P30291)
| PDB | External Database | Details |
|---|---|---|
| Gly 287 | - | expression tag |
| Ala 288 | - | expression tag |
| Gly 289 | - | expression tag |
| Ser 290 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 32440.9 | |
| Non-Polymers* | Number of molecules | 6 |
| Total formula weight | 814.2 | |
| All* | Total formula weight | 33255.1 |
