5VC3
CRYSTAL STRUCTURE OF HUMAN WEE1 KINASE DOMAIN IN COMPLEX WITH BOSUTINIB
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A | Wee1-like protein kinase | polymer | 289 | 32440.9 | 1 | UniProt (P30291) Pfam (PF00069) In PDB | Homo sapiens (Human) | WEE1hu,Wee1A kinase |
2 | A | 4-[(2,4-dichloro-5-methoxyphenyl)amino]-6-methoxy-7-[3-(4-methylpiperazin-1-yl)propoxy]quinoline-3-carbonitrile | non-polymer | 530.4 | 1 | Chemie (DB8) | |||
3 | A | 1,2-ETHANEDIOL | non-polymer | 62.1 | 4 | Chemie (EDO) | |||
4 | A | CHLORIDE ION | non-polymer | 35.5 | 1 | Chemie (CL) | |||
5 | water | water | 18.0 | 72 | Chemie (HOH) |
Sequence modifications
A: 291 - 575 (UniProt: P30291)
PDB | External Database | Details |
---|---|---|
Gly 287 | - | expression tag |
Ala 288 | - | expression tag |
Gly 289 | - | expression tag |
Ser 290 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 1 |
Total formula weight | 32440.9 | |
Non-Polymers* | Number of molecules | 6 |
Total formula weight | 814.2 | |
All* | Total formula weight | 33255.1 |