5VC0
Crystal structure of human CYP3A4 bound to ritonavir
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Cytochrome P450 3A4 | polymer | 487 | 55757.8 | 1 | UniProt (P08684) Pfam (PF00067) | Homo sapiens (Human) | 1,8-cineole 2-exo-monooxygenase,Albendazole monooxygenase,Albendazole sulfoxidase,CYPIIIA3,CYPIIIA4,Cholesterol 25-hydroxylase,Cytochrome P450 3A3,Cytochrome P450 HLp,Cytochrome P450 NF-25,Cytochrome P450-PCN1,Nifedipine oxidase,Quinine 3-monooxygenase,Taurochenodeoxycholate 6-alpha-hydroxylase |
| 2 | B (A) | PROTOPORPHYRIN IX CONTAINING FE | non-polymer | 616.5 | 1 | Chemie (HEM) | |||
| 3 | C (A) | RITONAVIR | non-polymer | 720.9 | 1 | BIRD (PRD_001001) Chemie (RIT) PubChem (5076) PubChem (60954) PubChem (16760215) PubChem (392622) PubChem (44325718) PubChem (45266310) PubChem (53487909) PubChem (54103495) PubChem (58662536) PubChem (66509020) PubChem (72942039) PubChem (72942040) PubChem (90717239) PubChem (455315) PubChem (10395099) PubChem (93535510) PubChem (92402731) PubChem (93535511) PubChem (93535509) PubChem (9853294) PubChem (135172324) PubChem (123133890) PubChem (133662525) PubChem (134602828) PubChem (134751724) PubChem (141861627) PubChem (169446189) PubChem (169446190) PubChem (170130299) |
Sequence modifications
A: 23 - 503 (UniProt: P08684)
| PDB | External Database | Details |
|---|---|---|
| Met 1 | - | SEE REMARK 999 |
| Ala 2 | - | SEE REMARK 999 |
| His 504 | - | expression tag |
| His 505 | - | expression tag |
| His 506 | - | expression tag |
| His 507 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 55757.8 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 1337.4 | |
| All* | Total formula weight | 57095.2 |
