5VBU
Crystal Structure of Human Cytochrome P450 21A2 Hydroxyprogesterone Complex
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C (A, B, C) | Cytochrome P450 21-hydroxylase | polymer | 476 | 53710.3 | 3 | UniProt (Q16874) Pfam (PF00067) UniProt (by SIFTS) (P08686) | Homo sapiens (Human) | Cytochrome P450,family 21,subfamily A,polypeptide 2,isoform CRA_b,DJ34F7.3 (Cytochrome P450,subfamily XXIA (Steroid 21-hydroxylase,congenital adrenal hyperplasia),polypeptide 2 (CYP21,P450c21B)),Steroid 21-hydroxylase,cDNA,FLJ95495,Homo sapiens cytochrome P450,polypeptide 2(CYP21A2),mRNA |
| 2 | D, F, H (A, B, C) | PROTOPORPHYRIN IX CONTAINING FE | non-polymer | 616.5 | 3 | Chemie (HEM) | |||
| 3 | E, G, I (A, B, C) | (9beta)-17-hydroxypregn-4-ene-3,20-dione | non-polymer | 330.5 | 3 | Chemie (3QZ) | |||
| 4 | J, K (A, B) | water | water | 18.0 | 5 | Chemie (HOH) |
Sequence modifications
A, B, C: 30 - 495 (UniProt: Q16874)
| PDB | External Database | Details |
|---|---|---|
| Met 20 | - | initiating methionine |
| Ala 21 | - | expression tag |
| Lys 22 | - | expression tag |
| Lys 23 | - | expression tag |
| Thr 24 | - | expression tag |
| Ser 25 | - | expression tag |
| Ser 26 | - | expression tag |
| Lys 27 | - | expression tag |
| Gly 28 | - | expression tag |
| Lys 29 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 3 |
| Total formula weight | 161130.9 | |
| Non-Polymers* | Number of molecules | 6 |
| Total formula weight | 2840.8 | |
| All* | Total formula weight | 163971.7 |
