5VBU
Crystal Structure of Human Cytochrome P450 21A2 Hydroxyprogesterone Complex
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C (A, B, C) | Cytochrome P450 21-hydroxylase | polymer | 476 | 53710.3 | 3 | UniProt (Q16874) Pfam (PF00067) UniProt (by SIFTS) (P08686) | Homo sapiens (Human) | Cytochrome P450,family 21,subfamily A,polypeptide 2,isoform CRA_b,DJ34F7.3 (Cytochrome P450,subfamily XXIA (Steroid 21-hydroxylase,congenital adrenal hyperplasia),polypeptide 2 (CYP21,P450c21B)),Steroid 21-hydroxylase,cDNA,FLJ95495,Homo sapiens cytochrome P450,polypeptide 2(CYP21A2),mRNA |
| 2 | D, F, H (A, B, C) | PROTOPORPHYRIN IX CONTAINING FE | non-polymer | 616.5 | 3 | Chemie (HEM) | |||
| 3 | E, G, I (A, B, C) | (9beta)-17-hydroxypregn-4-ene-3,20-dione | non-polymer | 330.5 | 3 | Chemie (3QZ) PubChem (16395880) PubChem (16758149) PubChem (16759250) PubChem (18530261) PubChem (6238) PubChem (71200612) PubChem (25762896) PubChem (29933816) PubChem (51410580) PubChem (1778808) PubChem (1778810) PubChem (1778806) PubChem (719694) PubChem (928565) PubChem (101793) PubChem (521928) PubChem (7076389) PubChem (124903235) PubChem (6603871) PubChem (6710628) PubChem (6918981) PubChem (7059644) PubChem (7076390) PubChem (7076391) PubChem (12624853) PubChem (124303825) PubChem (11872725) PubChem (11872726) PubChem (11872727) PubChem (12624852) PubChem (135012703) PubChem (138107689) PubChem (145875049) PubChem (166992003) PubChem (172011994) | |||
| 4 | J, K (A, B) | water | water | 18.0 | 5 | Chemie (HOH) |
Sequence modifications
A, B, C: 30 - 495 (UniProt: Q16874)
| PDB | External Database | Details |
|---|---|---|
| Met 20 | - | initiating methionine |
| Ala 21 | - | expression tag |
| Lys 22 | - | expression tag |
| Lys 23 | - | expression tag |
| Thr 24 | - | expression tag |
| Ser 25 | - | expression tag |
| Ser 26 | - | expression tag |
| Lys 27 | - | expression tag |
| Gly 28 | - | expression tag |
| Lys 29 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 3 |
| Total formula weight | 161130.9 | |
| Non-Polymers* | Number of molecules | 6 |
| Total formula weight | 2840.8 | |
| All* | Total formula weight | 163971.7 |
