5VAQ
Crystal Structure of Beta-Klotho in Complex with FGF21CT
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A | Beta-klotho | polymer | 954 | 109594.4 | 1 | UniProt (Q86Z14) Pfam (PF00232) In PDB | Homo sapiens (Human) | BetaKlotho,Klotho beta-like protein |
2 | B | Nb914 | polymer | 134 | 14837.5 | 1 | Lama glama | ||
3 | C | Fibroblast growth factor 21 | polymer | 24 | 2397.5 | 1 | UniProt (Q9NSA1) In PDB | Homo sapiens | FGF-21 |
4 | A | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 1 | Chemie (NAG) |
Sequence modifications
A: 30 - 983 (UniProt: Q86Z14)
C: 186 - 209 (UniProt: Q9NSA1)
PDB | External Database | Details |
---|---|---|
Gln 308 | Asn 308 | engineered mutation |
Gln 611 | Asn 611 | engineered mutation |
PDB | External Database | Details |
---|---|---|
Gly 199 | Pro 199 | conflict |
Glu 208 | Ala 208 | conflict |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 3 |
Total formula weight | 126829.4 | |
Non-Polymers* | Number of molecules | 1 |
Total formula weight | 221.2 | |
All* | Total formula weight | 127050.6 |