5VAQ
Crystal Structure of Beta-Klotho in Complex with FGF21CT
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Beta-klotho | polymer | 954 | 109594.4 | 1 | UniProt (Q86Z14) Pfam (PF00232) | Homo sapiens (Human) | BetaKlotho,Klotho beta-like protein |
| 2 | B (B) | Nb914 | polymer | 134 | 14837.5 | 1 | Lama glama | ||
| 3 | C (C) | Fibroblast growth factor 21 | polymer | 24 | 2397.5 | 1 | UniProt (Q9NSA1) | Homo sapiens | FGF-21 |
| 4 | D (A) | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 1 | Chemie (NAG) |
Sequence modifications
A: 30 - 983 (UniProt: Q86Z14)
C: 186 - 209 (UniProt: Q9NSA1)
| PDB | External Database | Details |
|---|---|---|
| Gln 308 | Asn 308 | engineered mutation |
| Gln 611 | Asn 611 | engineered mutation |
| PDB | External Database | Details |
|---|---|---|
| Gly 199 | Pro 199 | conflict |
| Glu 208 | Ala 208 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 3 |
| Total formula weight | 126829.4 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 221.2 | |
| All* | Total formula weight | 127050.6 |
