5VAI
Cryo-EM structure of the activated Glucagon-like peptide-1 receptor in complex with G protein
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | R | Uncharacterized protein | polymer | 461 | 52581.8 | 1 | UniProt (G1SGD4) Pfam (PF02793) Pfam (PF00002) In PDB | Oryctolagus cuniculus (Rabbit) | |
2 | P | Glucagon-like peptide 1 | polymer | 31 | 3359.7 | 1 | UniProt (P01275) Pfam (PF00123) In PDB | Homo sapiens | |
3 | A | Guanine nucleotide-binding protein G(s) subunit alpha isoforms short | polymer | 380 | 44370.2 | 1 | UniProt (P63092) Pfam (PF00503) In PDB | Homo sapiens (Human) | Adenylate cyclase-stimulating G alpha protein |
4 | B | Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 | polymer | 351 | 38744.4 | 1 | UniProt (P54311) Pfam (PF00400) In PDB | Rattus norvegicus (Rat) | Transducin beta chain 1 |
5 | G | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 | polymer | 68 | 7563.8 | 1 | UniProt (P63212) Pfam (PF00631) In PDB | Bos taurus (Bovine) | G gamma-I |
6 | N | nanobody 35 | polymer | 138 | 15140.7 | 1 | Lama glama |
Sequence modifications
R: 24 - 422 (UniProt: G1SGD4)
A: 1 - 394 (UniProt: P63092)
B: 2 - 340 (UniProt: P54311)
PDB | External Database | Details |
---|---|---|
Met -38 | - | expression tag |
Lys -37 | - | expression tag |
Thr -36 | - | expression tag |
Ile -35 | - | expression tag |
Ile -34 | - | expression tag |
Ala -33 | - | expression tag |
Leu -32 | - | expression tag |
Ser -31 | - | expression tag |
Tyr -30 | - | expression tag |
Ile -29 | - | expression tag |
Phe -28 | - | expression tag |
Cys -27 | - | expression tag |
Leu -26 | - | expression tag |
Val -25 | - | expression tag |
Phe -24 | - | expression tag |
Ala -23 | - | expression tag |
Asp -22 | - | expression tag |
Tyr -21 | - | expression tag |
Lys -20 | - | expression tag |
Asp -19 | - | expression tag |
Asp -18 | - | expression tag |
Asp -17 | - | expression tag |
Asp -16 | - | expression tag |
Ala -15 | - | expression tag |
Ala -14 | - | expression tag |
Ala -13 | - | expression tag |
Gly -12 | - | expression tag |
Gln -11 | - | expression tag |
Pro -10 | - | expression tag |
Gly -9 | - | expression tag |
Asn -8 | - | expression tag |
Gly -7 | - | expression tag |
Ser -6 | - | expression tag |
Ala -5 | - | expression tag |
Phe -4 | - | expression tag |
Leu -3 | - | expression tag |
Leu -2 | - | expression tag |
Ala -1 | - | expression tag |
Pro 0 | - | expression tag |
Asn 1 | - | expression tag |
Arg 2 | - | expression tag |
Ser 3 | - | expression tag |
His 4 | - | expression tag |
Ala 5 | - | expression tag |
Pro 6 | - | expression tag |
Gly 7 | - | expression tag |
Gly 8 | - | expression tag |
Gly 9 | - | expression tag |
Gly 10 | - | expression tag |
Ser 11 | - | expression tag |
Leu 12 | - | expression tag |
Glu 13 | - | expression tag |
Val 14 | - | expression tag |
Leu 15 | - | expression tag |
Phe 16 | - | expression tag |
Gln 17 | - | expression tag |
Gly 18 | - | expression tag |
Pro 19 | - | expression tag |
Gly 20 | - | expression tag |
Gly 21 | - | expression tag |
Gly 22 | - | expression tag |
Ser 23 | - | expression tag |
Ala 106 | Thr 106 | conflict |
Pro 112 | His 112 | conflict |
Arg 140 | Gln 140 | conflict |
PDB | External Database | Details |
---|---|---|
Asp 188 | Ala 174 | conflict |
PDB | External Database | Details |
---|---|---|
Met -10 | - | initiating methionine |
His -9 | - | expression tag |
His -8 | - | expression tag |
His -7 | - | expression tag |
His -6 | - | expression tag |
His -5 | - | expression tag |
His -4 | - | expression tag |
Gly -3 | - | expression tag |
Ser -2 | - | expression tag |
Leu -1 | - | expression tag |
Leu 0 | - | expression tag |
Gln 1 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 6 |
Total formula weight | 161760.5 | |
All* | Total formula weight | 161760.5 |