5VA3

Cryo-EM structure of the human ether-a-go-go related K+ channel

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	Potassium voltage-gated channel subfamily H member 2	polymer	795	88885.7	1	UniProt (Q12809) Pfam (PF13426) Pfam (PF00520) Pfam (PF07885) Pfam (PF00027)	Homo sapiens (Human)	Eag homolog, Ether-a-go-go-related gene potassium channel 1, hERG1, Voltage-gated potassium channel subunit Kv11.1

Sequence modifications

A: 1 - 380 (UniProt: Q12809)
A: 381 - 870 (UniProt: Q12809)

PDB	External Database	Details
Ala 631	Ser 631	engineered mutation

A: 871 - 1024 (UniProt: Q12809)

PDB	External Database	Details
Glu 1025	-	expression tag
Ala 1026	-	expression tag
Ser 1027	-	expression tag
Asn 1028	-	expression tag
Ser 1029	-	expression tag
Leu 1030	-	expression tag
Glu 1031	-	expression tag
Val 1032	-	expression tag
Leu 1033	-	expression tag
Phe 1034	-	expression tag
Gln 1035	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	1
	Total formula weight	88885.7
All*	Total formula weight	88885.7

*Water molecules are not included.