5V9J
Crystal structure of catalytic domain of GLP with MS0105
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Histone-lysine N-methyltransferase EHMT1 | polymer | 287 | 32974.3 | 2 | UniProt (Q9H9B1) Pfam (PF05033) Pfam (PF00856) | Homo sapiens (Human) | Euchromatic histone-lysine N-methyltransferase 1,Eu-HMTase1,G9a-like protein 1,GLP1,Histone H3-K9 methyltransferase 5,H3-K9-HMTase 5,Lysine N-methyltransferase 1D |
| 2 | C, R (A, B) | S-ADENOSYLMETHIONINE | non-polymer | 398.4 | 2 | Chemie (SAM) | |||
| 3 | D, S (A, B) | N~2~-cyclohexyl-N~4~-(1-ethylpiperidin-4-yl)-6,7-dimethoxy-N~2~-methylquinazoline-2,4-diamine | non-polymer | 427.6 | 2 | Chemie (90P) | |||
| 4 | E, F, G, H, T... (A, B) | ZINC ION | non-polymer | 65.4 | 8 | Chemie (ZN) | |||
| 5 | I, J, X (A, B) | CHLORIDE ION | non-polymer | 35.5 | 3 | Chemie (CL) | |||
| 6 | AA, BA, CA, DA, EA... (B, A) | UNKNOWN ATOM OR ION | non-polymer | 13 | Chemie (UNX) | ||||
| 7 | Y (B) | DIMETHYL SULFOXIDE | non-polymer | 78.1 | 1 | Chemie (DMS) | |||
| 8 | FA, GA (A, B) | water | water | 18.0 | 631 | Chemie (HOH) |
Sequence modifications
A, B: 982 - 1266 (UniProt: Q9H9B1)
| PDB | External Database | Details |
|---|---|---|
| Gly 980 | - | expression tag |
| Ser 981 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 65948.7 | |
| Non-Polymers* | Number of molecules | 29 |
| Total formula weight | 2359.8 | |
| All* | Total formula weight | 68308.5 |
