5V62
Phospho-ERK2 bound to bivalent inhibitor SBP3
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Mitogen-activated protein kinase 1 | polymer | 351 | 40918.8 | 1 | UniProt (P28482) Pfam (PF00069) | Homo sapiens (Human) | MAPK 1,ERT1,Extracellular signal-regulated kinase 2,ERK-2,MAP kinase isoform p42,p42-MAPK,Mitogen-activated protein kinase 2,MAPK 2 |
| 2 | B (I) | Ribosomal protein S6 kinase alpha-1 | polymer | 21 | 2396.9 | 1 | UniProt (Q15418) | Homo sapiens | S6K-alpha-1,90 kDa ribosomal protein S6 kinase 1,p90S6K,MAP kinase-activated protein kinase 1a,MAPKAPK-1a,Ribosomal S6 kinase 1,RSK-1 |
| 3 | C, D, E, F, G (A) | GLYCEROL | non-polymer | 92.1 | 5 | Chemie (GOL) | |||
| 4 | H (A) | 5-(2-PHENYLPYRAZOLO[1,5-A]PYRIDIN-3-YL)-1H-PYRAZOLO[3,4-C]PYRIDAZIN-3-AMINE | non-polymer | 327.3 | 1 | Chemie (FRZ) | |||
| 5 | I (A) | N-(hex-5-yn-1-yl)hexanamide | non-polymer | 195.3 | 1 | Chemie (AKS) | |||
| 6 | J (A) | water | water | 18.0 | 255 | Chemie (HOH) |
Sequence modifications
I: 713 - 729 (UniProt: Q15418)
| PDB | External Database | Details |
|---|---|---|
| Azk 709 | - | insertion |
| Gly 710 | - | insertion |
| Thr 711 | - | insertion |
| Ala 712 | - | insertion |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 43315.7 | |
| Non-Polymers* | Number of molecules | 7 |
| Total formula weight | 983.1 | |
| All* | Total formula weight | 44298.8 |
