5V4Y
X-ray crystal structure of wild type HIV-1 protease in complex with GRL-09510
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Protease | polymer | 99 | 10725.6 | 1 | UniProt (Q72874) Pfam (PF00077) | Human immunodeficiency virus 1 | |
| 2 | B (A) | (3S,3aR,5R,7aS,8S)-hexahydro-4H-3,5-methanofuro[2,3-b]pyran-8-yl [(2S,3R)-3-hydroxy-4-{[(4-methoxyphenyl)sulfonyl](2-methylpropyl)amino}-1-phenylbutan-2-yl]carbamate | non-polymer | 588.7 | 1 | Chemie (8FM) | |||
| 3 | C (A) | water | water | 18.0 | 73 | Chemie (HOH) |
Sequence modifications
A: 1 - 99 (UniProt: Q72874)
| PDB | External Database | Details |
|---|---|---|
| Ala 67 | Cys 67 | engineered mutation |
| Ala 95 | Cys 95 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 10725.6 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 588.7 | |
| All* | Total formula weight | 11314.3 |
