5V48
Soluble rabbit neprilysin in complex with thiorphan
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Neprilysin | polymer | 696 | 79479.4 | 2 | UniProt (P08049) Pfam (PF05649) Pfam (PF01431) | Oryctolagus cuniculus (Rabbit) | Atriopeptidase,Enkephalinase,Neutral endopeptidase 24.11,Neutral endopeptidase,Skin fibroblast elastase,SFE |
| 2 | C, D, E, F (C, D, E, F) | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 424.4 | 4 | In PDB GlyTouCan (G42666HT) | |||
| 3 | G, K (A, B) | ZINC ION | non-polymer | 65.4 | 2 | Chemie (ZN) | |||
| 4 | H, L (A, B) | (2-MERCAPTOMETHYL-3-PHENYL-PROPIONYL)-GLYCINE | non-polymer | 253.3 | 2 | Chemie (TIO) | |||
| 5 | I, J, M (A, B) | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 3 | Chemie (NAG) | |||
| 6 | N, O (A, B) | water | water | 18.0 | 736 | Chemie (HOH) |
Sequence modifications
A, B: 55 - 750 (UniProt: P08049)
| PDB | External Database | Details |
|---|---|---|
| Lys 194 | Asn 194 | variant |
| Ser 363 | Phe 363 | variant |
| Leu 367 | Phe 367 | conflict |
| Met 371 | Phe 371 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 158958.7 | |
| Branched | Number of molecules | 4 |
| Total formula weight | 1697.6 | |
| Non-Polymers* | Number of molecules | 7 |
| Total formula weight | 1301.1 | |
| All* | Total formula weight | 161957.4 |
