5V03
A positive allosteric modulator binding pocket in SK2 ion channels is shared by Riluzole and CyPPA
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (B) | Small conductance calcium-activated potassium channel protein 2 | polymer | 102 | 12243.4 | 1 | UniProt (Q9H2S1) Pfam (PF02888) | Homo sapiens (Human) | SKCa2,KCa2.2 |
| 2 | B (R) | Calmodulin | polymer | 149 | 16852.5 | 1 | UniProt (P62158) Pfam (PF13499) UniProt (by SIFTS) (P0DP23) | Homo sapiens (Human) | CaM |
| 3 | C (B) | SULFATE ION | non-polymer | 96.1 | 1 | Chemie (SO4) | |||
| 4 | D (R) | N-(4-chlorophenyl)-2-(3,5-dimethyl-1H-pyrazol-1-yl)pyrimidin-4-amine | non-polymer | 299.8 | 1 | Chemie (658) | |||
| 5 | E, F (R) | CALCIUM ION | non-polymer | 40.1 | 2 | Chemie (CA) | |||
| 6 | G, H (B, R) | water | water | 18.0 | 176 | Chemie (HOH) |
Sequence modifications
B: 396 - 487 (UniProt: Q9H2S1)
| PDB | External Database | Details |
|---|---|---|
| Met 394 | - | initiating methionine |
| Gly 395 | - | expression tag |
| Leu 488 | - | expression tag |
| Glu 489 | - | expression tag |
| His 490 | - | expression tag |
| His 491 | - | expression tag |
| His 492 | - | expression tag |
| His 493 | - | expression tag |
| His 494 | - | expression tag |
| His 495 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 29095.9 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 476.0 | |
| All* | Total formula weight | 29571.9 |
