5UZE

Crystal Structure of Inosine 5'-monophosphate Dehydrogenase from Clostridium perfringens Complexed with IMP and P182

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C, D (A, B, C, D)	Inosine-5'-monophosphate dehydrogenase,Inosine-5'-monophosphate dehydrogenase	polymer	363	38441.3	4	UniProt (A0A0H2YRZ7)	Clostridium perfringens (strain ATCC 13124 / DSM 756 / JCM 1290 / NCIMB 6125 / NCTC 8237 / Type A)	IMPDH
2	E, H, L, N (A, B, C, D)	INOSINIC ACID	non-polymer		348.2	4	Chemie (IMP) PubChem (177678963) PubChem (135464200) PubChem (135533971) PubChem (138454308) PubChem (135398640) PubChem (135402036) PubChem (135449337) PubChem (135486133) PubChem (135530792) PubChem (135567013) PubChem (135705234) PubChem (135854804) PubChem (135889742) PubChem (136026456) PubChem (136073920) PubChem (136217866) PubChem (136259539) PubChem (136716177) PubChem (136766861) PubChem (136811071) PubChem (137162990) PubChem (137168789) PubChem (137257909) PubChem (162510533) PubChem (174152734)
3	F, I, M, O (A, B, C, D)	N-{4-chloro-3-[4-(trifluoromethyl)-1,3-thiazol-2-yl]phenyl}-N'-(2-{3-[(1E)-N-hydroxyethanimidoyl]phenyl}propan-2-yl)urea	non-polymer		496.9	4	Chemie (8L1) PubChem (124219490) PubChem (124222457)
4	G, J (A, B)	POTASSIUM ION	non-polymer		39.1	2	Chemie (K) PubChem (813)
5	K (B)	GLYCEROL	non-polymer		92.1	1	Chemie (GOL) PubChem (753)
6	P, Q, R, S (A, B, C, D)	water	water		18.0	156	Chemie (HOH)

Sequence modifications

A, B, C, D: 1 - 88 (UniProt: A0A0H2YRZ7)

PDB	External Database	Details
Ser -2	-	expression tag
Asn -1	-	expression tag
Ala 0	-	expression tag

A, B, C, D: 216 - 484 (UniProt: A0A0H2YRZ7)

PDB	External Database	Details
Ser 89	-	linker
Gly 90	-	linker
Gly 91	-	linker

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	153765.1
Non-Polymers*	Number of molecules	11
	Total formula weight	3550.8
All*	Total formula weight	157315.9

*Water molecules are not included.