5UY8
Crystal structure of AICARFT bound to an antifolate
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, B, C, D | Bifunctional purine biosynthesis protein PURH | polymer | 601 | 65793.9 | 4 | UniProt (P31939) Pfam (PF02142) Pfam (PF01808) In PDB | Homo sapiens (Human) | |
2 | A, B, C, D | 5-[(5S)-5-ethyl-5-methyl-6-oxo-1,4,5,6-tetrahydropyridin-3-yl]-N-(6-fluoro-1-oxo-1,2-dihydroisoquinolin-7-yl)thiophene-2-sulfonamide | non-polymer | 461.5 | 4 | Chemie (8UM) | |||
3 | A, B, C, D | AMINOIMIDAZOLE 4-CARBOXAMIDE RIBONUCLEOTIDE | non-polymer | 338.2 | 7 | Chemie (AMZ) | |||
4 | A, B, C, D | MAGNESIUM ION | non-polymer | 24.3 | 4 | Chemie (MG) | |||
5 | water | water | 18.0 | 207 | Chemie (HOH) |
Sequence modifications
A, B, C, D: 2 - 592 (UniProt: P31939)
PDB | External Database | Details |
---|---|---|
Met -8 | - | expression tag |
Ala -7 | - | expression tag |
His -6 | - | expression tag |
His -5 | - | expression tag |
His -4 | - | expression tag |
His -3 | - | expression tag |
His -2 | - | expression tag |
His -1 | - | expression tag |
Ser 0 | - | expression tag |
Leu 1 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 4 |
Total formula weight | 263175.7 | |
Non-Polymers* | Number of molecules | 15 |
Total formula weight | 4310.8 | |
All* | Total formula weight | 267486.5 |