5UY8
Crystal structure of AICARFT bound to an antifolate
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D (A, B, C, D) | Bifunctional purine biosynthesis protein PURH | polymer | 601 | 65793.9 | 4 | UniProt (P31939) Pfam (PF02142) Pfam (PF01808) | Homo sapiens (Human) | |
| 2 | E, I, L, P (A, B, C, D) | 5-[(5S)-5-ethyl-5-methyl-6-oxo-1,4,5,6-tetrahydropyridin-3-yl]-N-(6-fluoro-1-oxo-1,2-dihydroisoquinolin-7-yl)thiophene-2-sulfonamide | non-polymer | 461.5 | 4 | Chemie (8UM) PubChem (121378614) PubChem (137348756) | |||
| 3 | F, G, J, M, N... (A, B, C, D) | AMINOIMIDAZOLE 4-CARBOXAMIDE RIBONUCLEOTIDE | non-polymer | 338.2 | 7 | Chemie (AMZ) PubChem (16760280) PubChem (25322835) PubChem (29971658) PubChem (29971663) PubChem (46874858) PubChem (46936194) PubChem (69015652) PubChem (200) PubChem (65110) PubChem (90004537) PubChem (92209412) PubChem (92209413) PubChem (92209414) PubChem (92209415) PubChem (159841653) PubChem (162938701) PubChem (163812830) PubChem (171699377) PubChem (173757272) | |||
| 4 | H, K, O, S (A, B, C, D) | MAGNESIUM ION | non-polymer | 24.3 | 4 | Chemie (MG) PubChem (888) | |||
| 5 | T, U, V, W (A, B, C, D) | water | water | 18.0 | 207 | Chemie (HOH) |
Sequence modifications
A, B, C, D: 2 - 592 (UniProt: P31939)
| PDB | External Database | Details |
|---|---|---|
| Met -8 | - | expression tag |
| Ala -7 | - | expression tag |
| His -6 | - | expression tag |
| His -5 | - | expression tag |
| His -4 | - | expression tag |
| His -3 | - | expression tag |
| His -2 | - | expression tag |
| His -1 | - | expression tag |
| Ser 0 | - | expression tag |
| Leu 1 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 263175.7 | |
| Non-Polymers* | Number of molecules | 15 |
| Total formula weight | 4310.8 | |
| All* | Total formula weight | 267486.5 |
