5UWT
Crystal Structure of Hxk2 Peptide in complex with CRM1 K579A mutant-Ran-RanBP1
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A | GTP-binding nuclear protein Ran | polymer | 237 | 26758.6 | 1 | UniProt (P62826) Pfam (PF00071) In PDB | Homo sapiens (Human) | Androgen receptor-associated protein 24, GTPase Ran, Ras-like protein TC4, Ras-related nuclear protein |
2 | B | Ran-specific GTPase-activating protein 1 | polymer | 143 | 16521.9 | 1 | UniProt (P41920) Pfam (PF00638) In PDB | Saccharomyces cerevisiae (Baker's yeast) | Chromosome stability protein 20, Perinuclear array-localized protein, Ran-binding protein 1, RANBP1 |
3 | C | Exportin-1 | polymer | 1024 | 117400.7 | 1 | UniProt (P30822) Pfam (PF03810) Pfam (PF08389) Pfam (PF18777) Pfam (PF18784) Pfam (PF18787) Pfam (PF08767) In PDB | Saccharomyces cerevisiae (Baker's yeast) | Chromosome region maintenance protein 1, Karyopherin-124 |
4 | D | Hexokinase-2 | polymer | 23 | 2675.0 | 1 | UniProt (by SIFTS) (P04807) In PDB | Saccharomyces cerevisiae (Baker's yeast) | |
5 | A | PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER | non-polymer | 522.2 | 1 | Chemie (GNP) | |||
6 | A | MAGNESIUM ION | non-polymer | 24.3 | 1 | Chemie (MG) | |||
7 | A, C | GLYCEROL | non-polymer | 92.1 | 4 | Chemie (GOL) | |||
8 | water | water | 18.0 | 471 | Chemie (HOH) |
Sequence modifications
A: 1 - 216 (UniProt: P62826)
B: 62 - 201 (UniProt: P41920)
C: 1 - 376 (UniProt: P30822)
C: 414 - 1058 (UniProt: P30822)
PDB | External Database | Details |
---|---|---|
Met -20 | - | expression tag |
Glu -19 | - | expression tag |
Thr -18 | - | expression tag |
Gly -17 | - | expression tag |
Ser -16 | - | expression tag |
Ser -15 | - | expression tag |
His -14 | - | expression tag |
His -13 | - | expression tag |
His -12 | - | expression tag |
His -11 | - | expression tag |
His -10 | - | expression tag |
His -9 | - | expression tag |
Ser -8 | - | expression tag |
Ser -7 | - | expression tag |
Gly -6 | - | expression tag |
Leu -5 | - | expression tag |
Pro -4 | - | expression tag |
Arg -3 | - | expression tag |
Gly -2 | - | expression tag |
Ser -1 | - | expression tag |
His 0 | - | expression tag |
PDB | External Database | Details |
---|---|---|
Gly 59 | - | expression tag |
Gly 60 | - | expression tag |
Ser 61 | - | expression tag |
PDB | External Database | Details |
---|---|---|
Gly -2 | - | expression tag |
Gly -1 | - | expression tag |
Ser 0 | - | expression tag |
PDB | External Database | Details |
---|---|---|
Asp 441 | Val 441 | conflict |
Gly 537 | Asp 537 | conflict |
Cys 539 | Thr 539 | conflict |
Glu 540 | Val 540 | conflict |
Gln 541 | Lys 541 | conflict |
Ala 579 | Lys 579 | conflict |
Cys 1022 | Tyr 1022 | conflict |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 4 |
Total formula weight | 163356.1 | |
Non-Polymers* | Number of molecules | 6 |
Total formula weight | 914.9 | |
All* | Total formula weight | 164271.0 |