5USY

JAK2 JH1 in complex with JNJ-7706621

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B	Tyrosine-protein kinase JAK2	polymer	316	37398.4	2	UniProt (O60674) Pfam (PF07714) In PDB	Homo sapiens (Human)	Janus kinase 2,JAK-2
2	A, B	4-({5-amino-1-[(2,6-difluorophenyl)carbonyl]-1H-1,2,4-triazol-3-yl}amino)benzenesulfonamide	non-polymer		394.4	2	Chemie (SKE)
3	A, B	SULFATE ION	non-polymer		96.1	5	Chemie (SO4)
4	A, B	GLYCEROL	non-polymer		92.1	3	Chemie (GOL)
5		water	water		18.0	657	Chemie (HOH)

Sequence modifications

A, B: 840 - 1132 (UniProt: O60674)

PDB	External Database	Details
Ser 817	-	expression tag
Tyr 818	-	expression tag
Tyr 819	-	expression tag
His 820	-	expression tag
His 821	-	expression tag
His 822	-	expression tag
His 823	-	expression tag
His 824	-	expression tag
His 825	-	expression tag
Asp 826	-	expression tag
Tyr 827	-	expression tag
Asp 828	-	expression tag
Ile 829	-	expression tag
Pro 830	-	expression tag
Thr 831	-	expression tag
Thr 832	-	expression tag
Glu 833	-	expression tag
Asn 834	-	expression tag
Leu 835	-	expression tag
Tyr 836	-	expression tag
Phe 837	-	expression tag
Gln 838	-	expression tag
Gly 839	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	74796.8
Non-Polymers*	Number of molecules	10
	Total formula weight	1545.3
All*	Total formula weight	76342.1

*Water molecules are not included.