5USY
JAK2 JH1 in complex with JNJ-7706621
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Tyrosine-protein kinase JAK2 | polymer | 316 | 37398.4 | 2 | UniProt (O60674) Pfam (PF07714) | Homo sapiens (Human) | Janus kinase 2,JAK-2 |
| 2 | C, H (A, B) | 4-({5-amino-1-[(2,6-difluorophenyl)carbonyl]-1H-1,2,4-triazol-3-yl}amino)benzenesulfonamide | non-polymer | 394.4 | 2 | Chemie (SKE) | |||
| 3 | D, E, I, J, K (A, B) | SULFATE ION | non-polymer | 96.1 | 5 | Chemie (SO4) | |||
| 4 | F, G, L (A, B) | GLYCEROL | non-polymer | 92.1 | 3 | Chemie (GOL) | |||
| 5 | M, N (A, B) | water | water | 18.0 | 657 | Chemie (HOH) |
Sequence modifications
A, B: 840 - 1132 (UniProt: O60674)
| PDB | External Database | Details |
|---|---|---|
| Ser 817 | - | expression tag |
| Tyr 818 | - | expression tag |
| Tyr 819 | - | expression tag |
| His 820 | - | expression tag |
| His 821 | - | expression tag |
| His 822 | - | expression tag |
| His 823 | - | expression tag |
| His 824 | - | expression tag |
| His 825 | - | expression tag |
| Asp 826 | - | expression tag |
| Tyr 827 | - | expression tag |
| Asp 828 | - | expression tag |
| Ile 829 | - | expression tag |
| Pro 830 | - | expression tag |
| Thr 831 | - | expression tag |
| Thr 832 | - | expression tag |
| Glu 833 | - | expression tag |
| Asn 834 | - | expression tag |
| Leu 835 | - | expression tag |
| Tyr 836 | - | expression tag |
| Phe 837 | - | expression tag |
| Gln 838 | - | expression tag |
| Gly 839 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 74796.8 | |
| Non-Polymers* | Number of molecules | 10 |
| Total formula weight | 1545.3 | |
| All* | Total formula weight | 76342.1 |
