5URQ

Crystal Structure of the Catalytic Domain of the Inosine Monophosphate Dehydrogenase from Campylobacter jejuni in the complex with inhibitor p176

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C, D, E... (A, B, C, D, E...)	Inosine-5'-monophosphate dehydrogenase	polymer	406	43524.8	8	UniProt (A0A1B3XFT6) UniProt (A5KFK9)	Campylobacter jejuni subsp. jejuni	IMPDH
2	BA, EA, I, M, P... (H, G, A, B, C...)	INOSINIC ACID	non-polymer		348.2	8	Chemie (IMP)
3	CA, FA, J, N, Q... (H, G, A, B, C...)	N-{2-chloro-5-[({2-[3-(prop-1-en-2-yl)phenyl]propan-2-yl}carbamoyl)amino]phenyl}-alpha-D-ribofuranosylamine	non-polymer		476.0	8	Chemie (8L7)
4	AA, DA, K, L, O... (F, G, A, B, D...)	POTASSIUM ION	non-polymer		39.1	8	Chemie (K)
5	GA, HA, IA, JA, KA... (A, B, D, E, F...)	water	water		18.0	17	Chemie (HOH)

Sequence modifications

A, B, C, D, E, F, H, G: 1 - 194 (UniProt: A0A1B3XFT6)

PDB	External Database	Details
Met -23	-	initiating methionine
His -22	-	expression tag
His -21	-	expression tag
His -20	-	expression tag
His -19	-	expression tag
His -18	-	expression tag
His -17	-	expression tag
Ser -16	-	expression tag
Ser -15	-	expression tag
Gly -14	-	expression tag
Val -13	-	expression tag
Asp -12	-	expression tag
Leu -11	-	expression tag
Gly -10	-	expression tag
Thr -9	-	expression tag
Glu -8	-	expression tag
Asn -7	-	expression tag
Leu -6	-	expression tag
Tyr -5	-	expression tag
Phe -4	-	expression tag
Gln -3	-	expression tag
Ser -2	-	expression tag
Asn -1	-	expression tag
Ala 0	-	expression tag
Gly 195	-	linker

A, B, C, D, E, F, H, G: 196 - 485 (UniProt: A5KFK9)

Contents of the asymmetric unit

Polymers	Number of chains	8
	Total formula weight	348198.6
Non-Polymers*	Number of molecules	24
	Total formula weight	6906.2
All*	Total formula weight	355104.7

*Water molecules are not included.