5UQF
Crystal Structure of the Catalytic Domain of the Inosine Monophosphate Dehydrogenase from Campylobacter jejuni in the complex with IMP and the inhibitor P225
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C (A, B, C) | Inosine-5'-monophosphate dehydrogenase | polymer | 406 | 43524.8 | 3 | UniProt (A0A1B3XFT6) UniProt (A5KFK9) | Campylobacter jejuni subsp. jejuni | IMPDH |
| 2 | D, N, Y (A, B, C) | INOSINIC ACID | non-polymer | 348.2 | 3 | Chemie (IMP) | |||
| 3 | E, O, Z (A, B, C) | {2-chloro-5-[({2-[3-(prop-1-en-2-yl)phenyl]propan-2-yl}carbamoyl)amino]phenoxy}acetic acid | non-polymer | 402.9 | 3 | Chemie (8KY) | |||
| 4 | AA, F, P (C, A, B) | POTASSIUM ION | non-polymer | 39.1 | 3 | Chemie (K) | |||
| 5 | BA, CA, G, H, I... (C, A, B) | SULFATE ION | non-polymer | 96.1 | 10 | Chemie (SO4) | |||
| 6 | J, K, L, M, W... (A, B) | 1,2-ETHANEDIOL | non-polymer | 62.1 | 6 | Chemie (EDO) | |||
| 7 | DA, V (C, B) | GLYCEROL | non-polymer | 92.1 | 2 | Chemie (GOL) | |||
| 8 | EA, FA (C) | CHLORIDE ION | non-polymer | 35.5 | 2 | Chemie (CL) | |||
| 9 | GA, HA, IA (A, B, C) | water | water | 18.0 | 70 | Chemie (HOH) |
Sequence modifications
A, B, C: 1 - 194 (UniProt: A0A1B3XFT6)
A, B, C: 196 - 485 (UniProt: A5KFK9)
| PDB | External Database | Details |
|---|---|---|
| Met -23 | - | initiating methionine |
| His -22 | - | expression tag |
| His -21 | - | expression tag |
| His -20 | - | expression tag |
| His -19 | - | expression tag |
| His -18 | - | expression tag |
| His -17 | - | expression tag |
| Ser -16 | - | expression tag |
| Ser -15 | - | expression tag |
| Gly -14 | - | expression tag |
| Val -13 | - | expression tag |
| Asp -12 | - | expression tag |
| Leu -11 | - | expression tag |
| Gly -10 | - | expression tag |
| Thr -9 | - | expression tag |
| Glu -8 | - | expression tag |
| Asn -7 | - | expression tag |
| Leu -6 | - | expression tag |
| Tyr -5 | - | expression tag |
| Phe -4 | - | expression tag |
| Gln -3 | - | expression tag |
| Ser -2 | - | expression tag |
| Asn -1 | - | expression tag |
| Ala 0 | - | expression tag |
| Gly 195 | - | linker |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 3 |
| Total formula weight | 130574.5 | |
| Non-Polymers* | Number of molecules | 29 |
| Total formula weight | 3958.7 | |
| All* | Total formula weight | 134533.1 |
