5UQF
Crystal Structure of the Catalytic Domain of the Inosine Monophosphate Dehydrogenase from Campylobacter jejuni in the complex with IMP and the inhibitor P225
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, B, C | Inosine-5'-monophosphate dehydrogenase | polymer | 406 | 43524.8 | 3 | UniProt (A0A1B3XFT6) UniProt (A5KFK9) In PDB | Campylobacter jejuni subsp. jejuni | IMPDH |
2 | A, B, C | INOSINIC ACID | non-polymer | 348.2 | 3 | Chemie (IMP) | |||
3 | A, B, C | {2-chloro-5-[({2-[3-(prop-1-en-2-yl)phenyl]propan-2-yl}carbamoyl)amino]phenoxy}acetic acid | non-polymer | 402.9 | 3 | Chemie (8KY) | |||
4 | C, A, B | POTASSIUM ION | non-polymer | 39.1 | 3 | Chemie (K) | |||
5 | C, A, B | SULFATE ION | non-polymer | 96.1 | 10 | Chemie (SO4) | |||
6 | A, B | 1,2-ETHANEDIOL | non-polymer | 62.1 | 6 | Chemie (EDO) | |||
7 | C, B | GLYCEROL | non-polymer | 92.1 | 2 | Chemie (GOL) | |||
8 | C | CHLORIDE ION | non-polymer | 35.5 | 2 | Chemie (CL) | |||
9 | water | water | 18.0 | 70 | Chemie (HOH) |
Sequence modifications
A, B, C: 1 - 194 (UniProt: A0A1B3XFT6)
A, B, C: 196 - 485 (UniProt: A5KFK9)
PDB | External Database | Details |
---|---|---|
Met -23 | - | initiating methionine |
His -22 | - | expression tag |
His -21 | - | expression tag |
His -20 | - | expression tag |
His -19 | - | expression tag |
His -18 | - | expression tag |
His -17 | - | expression tag |
Ser -16 | - | expression tag |
Ser -15 | - | expression tag |
Gly -14 | - | expression tag |
Val -13 | - | expression tag |
Asp -12 | - | expression tag |
Leu -11 | - | expression tag |
Gly -10 | - | expression tag |
Thr -9 | - | expression tag |
Glu -8 | - | expression tag |
Asn -7 | - | expression tag |
Leu -6 | - | expression tag |
Tyr -5 | - | expression tag |
Phe -4 | - | expression tag |
Gln -3 | - | expression tag |
Ser -2 | - | expression tag |
Asn -1 | - | expression tag |
Ala 0 | - | expression tag |
Gly 195 | - | linker |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 3 |
Total formula weight | 130574.5 | |
Non-Polymers* | Number of molecules | 29 |
Total formula weight | 3958.7 | |
All* | Total formula weight | 134533.1 |