5UOY
Crystal structure of human PDE1B catalytic domain in complex with inhibitor 16j (6-(4-Methoxybenzyl)-9-((tetrahydro-2H-pyran-4-yl)methyl)-8,9,10,11-tetrahydropyrido[4',3':4,5]thieno[3,2-e][1,2,4]triazolo[1,5-c]pyrimidin-5(6H)-one)
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A | Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B | polymer | 361 | 41279.0 | 1 | UniProt (Q01064) Pfam (PF00233) In PDB | Homo sapiens (Human) | Cam-PDE 1B,63 kDa Cam-PDE |
| 2 | A | ZINC ION | non-polymer | 65.4 | 1 | Chemie (ZN) | |||
| 3 | A | MAGNESIUM ION | non-polymer | 24.3 | 1 | Chemie (MG) | |||
| 4 | A | 6-[(4-methoxyphenyl)methyl]-9-[(oxan-4-yl)methyl]-8,9,10,11-tetrahydropyrido[4',3':4,5]thieno[3,2-e][1,2,4]triazolo[1,5-c]pyrimidin-5(6H)-one | non-polymer | 465.6 | 2 | Chemie (8HM) | |||
| 5 | water | water | 18.0 | 140 | Chemie (HOH) |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 41279.0 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 1020.8 | |
| All* | Total formula weight | 42299.9 |
