Loading
PDBj
MenuPDBj@FacebookPDBj@TwitterPDBj@YouTubewwPDB FoundationwwPDB
RCSB PDBPDBeBMRBAdv. SearchSearch help

5UOX

Structure-Based Design of ASK1 Inhibitors as Potential First-in-Class Agents for Heart Failure

Entity
Entity IDChain IDDescriptionTypeChain lengthFormula weightNumber of moleculesDB Name (Accession)Biological sourceDescriptive keywords
1A, BMitogen-activated protein kinase kinase kinase 5polymer27130509.92UniProt (Q99683)
Pfam (PF00069)
In PDB
Homo sapiens (Human)Apoptosis signal-regulating kinase 1,ASK-1,MAPK/ERK kinase kinase 5,MEKK 5
2A, B2-(6-{4-[(2R)-1-hydroxypropan-2-yl]-4H-1,2,4-triazol-3-yl}pyridin-2-yl)-6-[(propan-2-yl)oxy]-2,3-dihydro-1H-isoindol-1-onenon-polymer393.42Chemie (8GY)
3waterwater18.070Chemie (HOH)
Sequence viewer
Contents of the asymmetric unit
PolymersNumber of chains2
Total formula weight61019.8
Non-Polymers*Number of molecules2
Total formula weight786.9
All*Total formula weight61806.7
*Water molecules are not included.

222415

PDB entries from 2024-07-10

PDB statisticsPDBj update infoContact PDBjnumon