5UOX
Structure-Based Design of ASK1 Inhibitors as Potential First-in-Class Agents for Heart Failure
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Mitogen-activated protein kinase kinase kinase 5 | polymer | 271 | 30509.9 | 2 | UniProt (Q99683) Pfam (PF00069) | Homo sapiens (Human) | Apoptosis signal-regulating kinase 1,ASK-1,MAPK/ERK kinase kinase 5,MEKK 5 |
| 2 | C, D (A, B) | 2-(6-{4-[(2R)-1-hydroxypropan-2-yl]-4H-1,2,4-triazol-3-yl}pyridin-2-yl)-6-[(propan-2-yl)oxy]-2,3-dihydro-1H-isoindol-1-one | non-polymer | 393.4 | 2 | Chemie (8GY) | |||
| 3 | E, F (A, B) | water | water | 18.0 | 70 | Chemie (HOH) |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 61019.8 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 786.9 | |
| All* | Total formula weight | 61806.7 |
