5UOW
Triheteromeric NMDA receptor GluN1/GluN2A/GluN2B in complex with glycine, glutamate, MK-801 and a GluN2B-specific Fab, at pH 6.5
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, C | N-methyl-D-aspartate receptor subunit NR1-8a | polymer | 814 | 91639.9 | 2 | UniProt (C0KD18) Pfam (PF01094) Pfam (PF10613) Pfam (PF00060) Pfam (PF00497) UniProt (by SIFTS) (A0A1L8F5J9) In PDB | Xenopus laevis (African clawed frog) | |
2 | B | N-methyl-D-aspartate receptor subunit NR2A | polymer | 832 | 93664.3 | 1 | UniProt (B7ZSK1) Pfam (PF01094) Pfam (PF10613) Pfam (PF00060) Pfam (PF00497) In PDB | Xenopus laevis (African clawed frog) | |
3 | D | Ionotropic glutamate receptor subunit NR2B | polymer | 837 | 94552.2 | 1 | UniProt (A7XY94) Pfam (PF01094) Pfam (PF10613) Pfam (PF00060) Pfam (PF00497) In PDB | Xenopus laevis (African clawed frog) | |
4 | F, G | GluN2B-specific Fab, termed 11D1 | polymer | 216 | 18400.6 | 2 | Mus musculus | ||
5 | E, H, I, J, K... | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 424.4 | 8 | In PDB GlyTouCan (G42666HT) | |||
6 | B | GLUTAMIC ACID | non-polymer | 147.1 | 1 | Chemie (GLU) | |||
7 | B | (5S,10R)-5-methyl-10,11-dihydro-5H-5,10-epiminodibenzo[a,d][7]annulene | non-polymer | 221.3 | 1 | Chemie (BMK) |
Sequence modifications
A, C: 23 - 836 (UniProt: C0KD18)
B: 1 - 830 (UniProt: B7ZSK1)
D: 1 - 836 (UniProt: A7XY94)
PDB | External Database | Details |
---|---|---|
Gln 300 | Asn 300 | conflict |
Gln 350 | Asn 350 | conflict |
Asp 368 | Asn 368 | conflict |
Asp 440 | Asn 440 | conflict |
Asp 469 | Asn 469 | conflict |
Ala 493 | Lys 493 | conflict |
Ala 494 | Lys 494 | conflict |
Ala 495 | Glu 495 | conflict |
Ala 592 | Glu 592 | conflict |
Ala 593 | Glu 593 | conflict |
Ala 594 | Glu 594 | conflict |
Arg 610 | Gly 610 | conflict |
Leu 617 | Ile 617 | conflict |
Leu 636 | Gly 636 | conflict |
Arg 656 | Asp 656 | conflict |
Asp 741 | Lys 741 | conflict |
Glu 769 | Asn 769 | conflict |
Tyr 816 | Met 816 | conflict |
PDB | External Database | Details |
---|---|---|
Gln 67 | Asn 67 | conflict |
Ala 372 | Asn 372 | conflict |
- | Thr 386 | deletion |
- | Ala 387 | deletion |
- | Ser 388 | deletion |
- | Leu 389 | deletion |
Ala 431 | Asn 435 | conflict |
Ala 529 | Asn 533 | conflict |
Leu 605 | Val 609 | conflict |
Arg 644 | Glu 648 | conflict |
Arg 645 | Glu 649 | conflict |
Gln 675 | Asn 679 | conflict |
Lys 831 | - | expression tag |
Glu 832 | - | expression tag |
PDB | External Database | Details |
---|---|---|
Ser 20 | Met 20 | conflict |
Arg 21 | Gly 21 | conflict |
Ala 22 | Cys 22 | conflict |
Glu 64 | Ala 64 | conflict |
Gln 69 | Asn 69 | conflict |
Asp 343 | Asn 343 | conflict |
- | Lys 382 | deletion |
- | Tyr 383 | deletion |
- | Tyr 384 | deletion |
- | Val 385 | deletion |
Val 486 | Thr 490 | conflict |
Ala 581 | Cys 585 | conflict |
Leu 611 | Val 615 | conflict |
Arg 650 | Glu 654 | conflict |
Arg 651 | Glu 655 | conflict |
Tyr 836 | Phe 840 | conflict |
Lys 837 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 6 |
Total formula weight | 408297.5 | |
Branched | Number of molecules | 8 |
Total formula weight | 3395.2 | |
Non-Polymers* | Number of molecules | 2 |
Total formula weight | 368.4 | |
All* | Total formula weight | 412061.2 |