5UOQ
CRYSTAL STRUCTURE OF THE PROTOTYPE FOAMY VIRUS INTASOME WITH A 2- PYRIDINONE AMINAL INHIBITOR (COMPOUND 31)
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | INTEGRASE | polymer | 395 | 44456.7 | 2 | UniProt (P14350) Pfam (PF17921) Pfam (PF00665) Pfam (PF18103) | Human spumaretrovirus (SFVcpz(hu)) | Pr125Pol |
| 2 | C (C) | NUCLEOTIDE PREPROCESSED PFV DONOR DNA (NON-TRANSFERRED STRAND) | polymer | 19 | 5834.8 | 1 | Human spumaretrovirus | ||
| 3 | D (D) | NUCLEOTIDE PREPROCESSED PFV DONOR DNA (TRANSFERRED STRAND) | polymer | 17 | 5195.4 | 1 | Human spumaretrovirus | ||
| 4 | E (A) | ZINC ION | non-polymer | 65.4 | 1 | Chemie (ZN) | |||
| 5 | F, G, L, O, Q (A, B, C) | GLYCEROL | non-polymer | 92.1 | 5 | Chemie (GOL) | |||
| 6 | H, I, P (A, B) | MAGNESIUM ION | non-polymer | 24.3 | 3 | Chemie (MG) | |||
| 7 | J, K, N (A, B) | SULFATE ION | non-polymer | 96.1 | 3 | Chemie (SO4) | |||
| 8 | M (A) | (3R)-8-[(3-chloro-4-fluorophenyl)methyl]-6-hydroxy-1,5,7-trioxo-1,2',3',5,7,8,9,10-octahydro-2H-spiro[imidazo[5,1-a][2,6]naphthyridine-3,1'-indene]-7'-carbonitrile | non-polymer | 504.9 | 1 | Chemie (8G1) | |||
| 9 | R, S, T, U (A, B, C, D) | water | water | 18.0 | 180 | Chemie (HOH) |
Sequence modifications
A, B: 1 - 392 (UniProt: P14350)
| PDB | External Database | Details |
|---|---|---|
| Gly -2 | - | expression tag |
| Pro -1 | - | expression tag |
| Gly 0 | - | expression tag |
| Ser 217 | Gly 968 | engineered mutation |
| Gly 218 | Ser 969 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 99943.6 | |
| Non-Polymers* | Number of molecules | 13 |
| Total formula weight | 1391.9 | |
| All* | Total formula weight | 101335.5 |
