5UO9

Structure of human endothelial nitric oxide synthase heme domain in complex with 7-[(3-Ethyl-5-((methylamino)methyl)phenoxy)methyl]quinolin-2-amine

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C, D (A, B, C, D)	Nitric oxide synthase, endothelial	polymer	440	49345.8	4	UniProt (P29474) Pfam (PF02898)	Homo sapiens (Human)	Constitutive NOS,cNOS,EC-NOS,Endothelial NOS,eNOS,NOS type III,NOSIII
2	E, HA, O, Z (A, D, B, C)	PROTOPORPHYRIN IX CONTAINING FE	non-polymer		616.5	4	Chemie (HEM)
3	AA, F, IA, P (C, A, D, B)	5,6,7,8-TETRAHYDROBIOPTERIN	non-polymer		241.2	4	Chemie (H4B)
4	BA, G, JA, Q (C, A, D, B)	7-({3-ethyl-5-[(methylamino)methyl]phenoxy}methyl)quinolin-2-amine	non-polymer		321.4	4	Chemie (8J4)
5	CA, H, I, KA, LA... (C, A, D, B)	2-[BIS-(2-HYDROXY-ETHYL)-AMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL	non-polymer		209.2	12	Chemie (BTB)
6	DA, J (C, A)	ZINC ION	non-polymer		65.4	2	Chemie (ZN)
7	EA, K (C, A)	GLYCEROL	non-polymer		92.1	2	Chemie (GOL)
8	FA, L, OA, QA, V (C, A, D, B)	CHLORIDE ION	non-polymer		35.5	5	Chemie (CL)
9	GA, M, NA, W (C, A, D, B)	GADOLINIUM ATOM	non-polymer		157.3	4	Chemie (GD)
10	N (A)	CALCIUM ION	non-polymer		40.1	1	Chemie (CA)
11	PA (D)	MAGNESIUM ION	non-polymer		24.3	1	Chemie (MG)
12	RA, SA, TA, UA (A, B, C, D)	water	water		18.0	386	Chemie (HOH)

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	197383.1
Non-Polymers*	Number of molecules	39
	Total formula weight	8413.1
All*	Total formula weight	205796.2

*Water molecules are not included.