5UO7
Structure of human neuronal nitric oxide synthase heme domain in complex with (S)-3-[(2-amino-4-methylquinolin-7-yl)methoxy]-5-(2-(methylamino)propyl)benzonitrile
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B | Nitric oxide synthase, brain | polymer | 421 | 48784.5 | 2 | UniProt (P29475) Pfam (PF02898) In PDB | Homo sapiens (Human) | Constitutive NOS, NC-NOS, NOS type I, Neuronal NOS, nNOS, Peptidyl-cysteine S-nitrosylase NOS1, bNOS |
| 2 | A, B | PROTOPORPHYRIN IX CONTAINING FE | non-polymer | 616.5 | 2 | Chemie (HEM) | |||
| 3 | A, B | 5,6,7,8-TETRAHYDROBIOPTERIN | non-polymer | 241.2 | 2 | Chemie (H4B) | |||
| 4 | A, B | 3-[(2-amino-4-methylquinolin-7-yl)methoxy]-5-[(2S)-2-(methylamino)propyl]benzonitrile | non-polymer | 360.5 | 2 | Chemie (8FD) | |||
| 5 | B | ZINC ION | non-polymer | 65.4 | 1 | Chemie (ZN) | |||
| 6 | water | water | 18.0 | 435 | Chemie (HOH) |
Sequence modifications
A, B: 302 - 722 (UniProt: P29475)
| PDB | External Database | Details |
|---|---|---|
| Ala 354 | Arg 354 | engineered mutation |
| Asp 357 | Gly 357 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 97569.0 | |
| Non-Polymers* | Number of molecules | 7 |
| Total formula weight | 2501.8 | |
| All* | Total formula weight | 100070.8 |
