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5UO5

Structure of human neuronal nitric oxide synthase heme domain in complex with (RS)-3-[(2-amino-4-methylquinolin-7-yl)methoxy]-5-(2-(methylamino)propyl)benzonitrile

Entity
Entity IDChain IDDescriptionTypeChain lengthFormula weightNumber of moleculesDB Name (Accession)Biological sourceDescriptive keywords
1A, B
(A, B)
Nitric oxide synthase, brainpolymer42148784.52UniProt (P29475)
Pfam (PF02898)
Homo sapiens (Human)Constitutive NOS, NC-NOS, NOS type I, Neuronal NOS, nNOS, Peptidyl-cysteine S-nitrosylase NOS1, bNOS
2C, H
(A, B)
PROTOPORPHYRIN IX CONTAINING FEnon-polymer616.52Chemie (HEM)
3D, I
(A, B)
5,6,7,8-TETRAHYDROBIOPTERINnon-polymer241.22Chemie (H4B)
4E, J
(A, B)
3-[(2-amino-4-methylquinolin-7-yl)methoxy]-5-[(2R)-2-(methylamino)propyl]benzonitrilenon-polymer360.52Chemie (M4R)
5F, K
(A, B)
3-[(2-amino-4-methylquinolin-7-yl)methoxy]-5-[(2S)-2-(methylamino)propyl]benzonitrilenon-polymer360.52Chemie (8FD)
6G
(A)
ZINC IONnon-polymer65.41Chemie (ZN)
7L, M
(A, B)
waterwater18.0519Chemie (HOH)
Sequence modifications
A, B: 302 - 722 (UniProt: P29475)
PDBExternal DatabaseDetails
Ala 354Arg 354engineered mutation
Asp 357Gly 357engineered mutation
Sequence viewer
Contents of the asymmetric unit
PolymersNumber of chains2
Total formula weight97569.0
Non-Polymers*Number of molecules9
Total formula weight3222.7
All*Total formula weight100791.7
*Water molecules are not included.

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PDB entries from 2025-07-30

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