5UO1
Structure of human neuronal nitric oxide synthase heme domain in complex with 3-[(2-aminoquinolin-7-yl)methoxy]-5-((methylamino)methyl)benzonitrile
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, B | Nitric oxide synthase, brain | polymer | 421 | 48784.5 | 2 | UniProt (P29475) Pfam (PF02898) In PDB | Homo sapiens (Human) | Constitutive NOS, NC-NOS, NOS type I, Neuronal NOS, nNOS, Peptidyl-cysteine S-nitrosylase NOS1, bNOS |
2 | A, B | PROTOPORPHYRIN IX CONTAINING FE | non-polymer | 616.5 | 2 | Chemie (HEM) | |||
3 | A, B | 5,6,7,8-TETRAHYDROBIOPTERIN | non-polymer | 241.2 | 2 | Chemie (H4B) | |||
4 | A, B | 3-[(2-aminoquinolin-7-yl)methoxy]-5-[(methylamino)methyl]benzonitrile | non-polymer | 318.4 | 2 | Chemie (8EV) | |||
5 | A | GLYCEROL | non-polymer | 92.1 | 1 | Chemie (GOL) | |||
6 | A | ZINC ION | non-polymer | 65.4 | 1 | Chemie (ZN) | |||
7 | water | water | 18.0 | 719 | Chemie (HOH) |
Sequence modifications
A, B: 302 - 722 (UniProt: P29475)
PDB | External Database | Details |
---|---|---|
Ala 354 | Arg 354 | engineered mutation |
Asp 357 | Gly 357 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 2 |
Total formula weight | 97569.0 | |
Non-Polymers* | Number of molecules | 8 |
Total formula weight | 2509.7 | |
All* | Total formula weight | 100078.7 |