5UIQ

Crystal structure of IRAK4 in complex with compound 9

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C, D (A, B, C, D)	Interleukin-1 receptor-associated kinase 4	polymer	323	36584.0	4	UniProt (Q9NWZ3) Pfam (PF07714)	Homo sapiens (Human)	IRAK-4,Renal carcinoma antigen NY-REN-64
2	E, F, G, H (A, B, C, D)	2-[(propan-2-yl)oxy]benzamide	non-polymer		179.2	4	Chemie (8BV)
3	I, J, K, L (A, B, C, D)	water	water		18.0	63	Chemie (HOH)

Sequence modifications

A, B, C, D: 154 - 460 (UniProt: Q9NWZ3)

PDB	External Database	Details
Met 138	-	initiating methionine
His 139	-	expression tag
His 140	-	expression tag
His 141	-	expression tag
His 142	-	expression tag
His 143	-	expression tag
His 144	-	expression tag
Gly 145	-	expression tag
Gly 146	-	expression tag
Glu 147	-	expression tag
Asn 148	-	expression tag
Leu 149	-	expression tag
Tyr 150	-	expression tag
Phe 151	-	expression tag
Gln 152	-	expression tag
Gly 153	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	146336.1
Non-Polymers*	Number of molecules	4
	Total formula weight	716.9
All*	Total formula weight	147052.9

*Water molecules are not included.