5UI0
Crystal Structure of the Tyrosine Kinase Domain of FGF Receptor 2 harboring an E565A/K659M Double Gain-of-Function Mutation
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Fibroblast growth factor receptor 2 | polymer | 324 | 37054.6 | 2 | UniProt (P21802) Pfam (PF07714) | Homo sapiens (Human) | FGFR-2,K-sam,KGFR,Keratinocyte growth factor receptor |
| 2 | C, E (A, B) | CITRATE ANION | non-polymer | 189.1 | 2 | Chemie (FLC) | |||
| 3 | D (A) | SULFATE ION | non-polymer | 96.1 | 1 | Chemie (SO4) | |||
| 4 | F (B) | PHOSPHOMETHYLPHOSPHONIC ACID ADENYLATE ESTER | non-polymer | 505.2 | 1 | Chemie (ACP) | |||
| 5 | G, H (A, B) | water | water | 18.0 | 258 | Chemie (HOH) |
Sequence modifications
A, B: 458 - 768 (UniProt: P21802)
| PDB | External Database | Details |
|---|---|---|
| Met 445 | - | initiating methionine |
| Gly 446 | - | expression tag |
| Ser 447 | - | expression tag |
| Ser 448 | - | expression tag |
| His 449 | - | expression tag |
| His 450 | - | expression tag |
| His 451 | - | expression tag |
| His 452 | - | expression tag |
| His 453 | - | expression tag |
| His 454 | - | expression tag |
| Ser 455 | - | expression tag |
| Gln 456 | - | expression tag |
| Asp 457 | - | expression tag |
| Ala 491 | Cys 374 | engineered mutation |
| Ala 565 | Glu 448 | engineered mutation |
| Met 659 | Lys 542 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 74109.1 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 979.5 | |
| All* | Total formula weight | 75088.6 |
