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5UH6

Crystal structure of Mycobacterium tuberculosis transcription initiation complex containing 2ntRNA in complex with Rifampin

Entity
Entity IDChain IDDescriptionTypeChain lengthFormula weightNumber of moleculesDB Name (Accession)Biological sourceDescriptive keywords
1A, B
(A, B)		DNA-directed RNA polymerase subunit alphapolymer34737745.32UniProt (P9WGZ1)
Pfam (PF01193)
Pfam (PF01000)
Pfam (PF03118)		Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)RNAP subunit alpha,RNA polymerase subunit alpha,Transcriptase subunit alpha
2C
(C)		DNA-directed RNA polymerase subunit betapolymer1178130018.81UniProt (P9WGY9)
Pfam (PF04563)
Pfam (PF04561)
Pfam (PF04565)
Pfam (PF10385)
Pfam (PF00562)
Pfam (PF04560)		Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)RNAP subunit beta,RNA polymerase subunit beta,Transcriptase subunit beta
3D
(D)		DNA-directed RNA polymerase subunit beta'polymer1316146969.01UniProt (P9WGY7)
Pfam (PF04997)
Pfam (PF00623)
Pfam (PF04983)
Pfam (PF05000)
Pfam (PF04998)		Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)RNAP subunit beta',RNA polymerase subunit beta',Transcriptase subunit beta'
4E
(E)		DNA-directed RNA polymerase subunit omegapolymer11011851.11UniProt (P9WGY5)
Pfam (PF01192)		Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)RNAP omega subunit,RNA polymerase omega subunit,Transcriptase subunit omega
5F
(F)		RNA polymerase sigma factor SigApolymer52857877.21UniProt (P9WGI1)
Pfam (PF00140)
Pfam (PF04542)
Pfam (PF04539)
Pfam (PF04545)		Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)Sigma-A
6G
(H)		DNA (5'-D(*TP*AP*TP*AP*AP*TP*GP*GP*GP*AP*GP*CP*TP*GP*TP*CP*AP*CP*GP*GP*AP*TP*G)-3')polymer237160.61Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
7H
(G)		DNA (5'-D(*CP*AP*TP*CP*CP*GP*TP*GP*AP*GP*TP*CP*CP*AP*GP*G)-3')polymer164899.21Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
8I
(I)		RNA (5'-R(*GP*A)-3')polymer2629.51Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
9J
(C)		RIFAMPICINnon-polymer822.91Chemie (RFP)
PubChem (176795423)
PubChem (135403807)
PubChem (135398735)
PubChem (135441414)
PubChem (135499655)
PubChem (135484647)
PubChem (135449527)
PubChem (135484654)
PubChem (135512673)
PubChem (135671118)
PubChem (135678740)
PubChem (135603898)
PubChem (135583296)
PubChem (135762817)
PubChem (135665293)
PubChem (135889899)
PubChem (135802250)
PubChem (135887800)
PubChem (135921123)
PubChem (135857107)
PubChem (135876149)
PubChem (135887798)
PubChem (135925261)
PubChem (135900090)
PubChem (135972658)
PubChem (135928731)
PubChem (136023866)
PubChem (136136478)
PubChem (136122621)
PubChem (136170985)
PubChem (136238056)
PubChem (136257952)
PubChem (136226255)
PubChem (136254574)
PubChem (136504372)
PubChem (136653818)
PubChem (136619758)
PubChem (137007092)
PubChem (136594454)
PubChem (136621208)
PubChem (136646928)
PubChem (137097436)
PubChem (137097438)
PubChem (137086834)
PubChem (137091153)
PubChem (137108668)
PubChem (137191444)
PubChem (137154388)
PubChem (137184359)
PubChem (137154390)
PubChem (137159087)
PubChem (137177954)
PubChem (137229761)
PubChem (137222345)
PubChem (137208337)
PubChem (137218464)
PubChem (137267378)
PubChem (137286743)
PubChem (137704761)
PubChem (138106897)
PubChem (153274061)
PubChem (154075449)
PubChem (155556302)
PubChem (162984936)
PubChem (163059759)
PubChem (165729089)
PubChem (171360673)
PubChem (171686453)
PubChem (171699545)
PubChem (172916695)
PubChem (172995356)
PubChem (173717570)
PubChem (175653389)
PubChem (135476790)
PubChem (135550179)
PubChem (135582338)
PubChem (135584810)
PubChem (135665270)
PubChem (135738853)
PubChem (135781042)
PubChem (135802251)
PubChem (135814583)
PubChem (135822715)
PubChem (135887799)
PubChem (135889901)
PubChem (135915642)
PubChem (135921134)
PubChem (135925249)
PubChem (135925741)
PubChem (135932822)
PubChem (136153113)
PubChem (136246612)
PubChem (136250494)
PubChem (136257946)
PubChem (136257949)
PubChem (136265302)
PubChem (136598085)
PubChem (136601293)
PubChem (136620716)
PubChem (136631923)
PubChem (136709103)
PubChem (137016821)
PubChem (137091122)
PubChem (137092548)
PubChem (137092933)
PubChem (137097437)
PubChem (137097439)
PubChem (137138798)
PubChem (137154389)
PubChem (137154391)
PubChem (137169073)
PubChem (137208355)
PubChem (137225336)
PubChem (137229762)
PubChem (137251213)
PubChem (137270779)
PubChem (137270910)
PubChem (138756139)
PubChem (162984937)
PubChem (171336500)
PubChem (172966639)
PubChem (172987825)
PubChem (173493550)
10K, L
(D)		ZINC IONnon-polymer65.42Chemie (ZN)
11M
(D)		MAGNESIUM IONnon-polymer24.31Chemie (MG)
PubChem (888)
Sequence viewer
Contents of the asymmetric unit
PolymersNumber of chains9
Total formula weight434896.0
Non-Polymers*Number of molecules4
Total formula weight978.1
All*Total formula weight435874.1
*Water molecules are not included.

251174

PDB entries from 2026-03-25

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