5UFW
Estrogen Receptor Alpha Ligand Binding Domain in Complex with OP1154
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Estrogen receptor | polymer | 249 | 28355.2 | 2 | UniProt (P03372) Pfam (PF00104) | Homo sapiens (Human) | ER,ER-alpha,Estradiol receptor,Nuclear receptor subfamily 3 group A member 1 |
| 2 | C, D (A, B) | (2S)-3-(4-hydroxyphenyl)-4-methyl-2-(4-{2-[(3S)-3-methylpyrrolidin-1-yl]ethoxy}phenyl)-2H-1-benzopyran-7-ol | non-polymer | 457.6 | 2 | Chemie (86V) | |||
| 3 | E, F (A, B) | water | water | 18.0 | 623 | Chemie (HOH) |
Sequence modifications
A, B: 306 - 554 (UniProt: P03372)
| PDB | External Database | Details |
|---|---|---|
| Ser 381 | Cys 381 | engineered mutation |
| Ser 417 | Cys 417 | engineered mutation |
| Ser 530 | Cys 530 | engineered mutation |
| Ser 536 | Leu 536 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 56710.4 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 915.1 | |
| All* | Total formula weight | 57625.5 |
