5UC6

Structural insights into IL-1 alpha recognition by a naphthyl-modified aptamer that mimics IL-1RI Domain III

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	Interleukin-1 alpha	polymer	159	18064.5	1	UniProt (P01583) Pfam (PF00340)	Homo sapiens (Human)	IL-1 alpha,Hematopoietin-1
2	B (B)	DNA (5'-D(*CP*G)-R(P*(85Y))-D(P*GP*AP*G)-R(P*(85Y)P*(85Y))-D(P*A)-R(P*(85Y))-D(P*GP*GP*G)-R(P*(85Y)P*(85Y))-D(P*AP*GP*AP*G)-R(P*(85Y))-D(P*CP*GP*(ATD))-3')	polymer	23	8366.9	1		synthetic construct
3	C, E, F, G (A)	MAGNESIUM ION	non-polymer		24.3	4	Chemie (MG)
4	D (A)	SODIUM ION	non-polymer		23.0	1	Chemie (NA)
5	H (B)	PHOSPHATE ION	non-polymer		95.0	1	Chemie (PO4)
6	I, J (A, B)	water	water		18.0	145	Chemie (HOH)

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	26431.4
Non-Polymers*	Number of molecules	6
	Total formula weight	215.2
All*	Total formula weight	26646.6

*Water molecules are not included.